Naturalproductman’s Blog

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Archive for the ‘Metabolomics’ Category

Metabolomics

Posted by naturalproductman on December 19, 2012

At some point I’m going to need to review principal component analysis to truly understand this metabolomics study that identified a small molecule phermone.

ACIE paper

Posted in Computational, Mass Spectrometry, Metabolomics | Leave a Comment »

Desmosterol needed for HCV

Posted by naturalproductman on April 11, 2012

Priscilla Yang and co-workers from Harvard have reported in JACS on the identification of desmosterol needed for heptatitis C virus protein expression and viral genomic RNA.  I wonder why JACS has a green text background now in the articles instead of blue…

desmosterol

JACS paper

Posted in Chemical Biology, Diseases, Hepatitis C, Metabolomics, Steroids | Leave a Comment »

Phosphatidylcholine Leads to TMAO

Posted by naturalproductman on April 8, 2011

Stanley Hazen and co-workers in the Cleveland Clinic have reported in Nature on the metabolism of phosphatidyl choline, which gets converted to choline.  Choline in turn converts to trimethylamine by bacteria in the gut and trimethylamine turns into trimethylamine oxide by our flavin mono-oxygenase enzymes (FMO).  TMAO upregulates the expression of macrophage scavenger receptors.

phosphatidylcholine

 

Nature paper

Posted in Chemical Biology, Diseases, Heart, Metabolomics | Leave a Comment »

Valproic Acid Monitoring

Posted by naturalproductman on March 6, 2011

Renato Zenobi and colleagues at ETH Zurich have reported in Chem Comm on a way to detect the pharmacokinetics of valproic acid, a drug used to treat epilepsy.

valproic acid

Chem Comm paper

Posted in Chemical Biology, Enzymatic, Metabolomics, Methodology, New Setups, Pharmacokinetics | Leave a Comment »

 
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