Naturalproductman’s Blog

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Archive for the ‘Methodology’ Category

Δ9-THC synthesis

Posted by naturalproductman on October 11, 2014

Erick Carreira and co-workers have reported in ACIE on the synthesis of dehydrotetrahydrocannabinol.

THC

ACIE paper

Posted in Dual Catalysis, Methodology, Total Synthesis | Leave a Comment »

Interrupted Nazarov

Posted by naturalproductman on October 7, 2014

FG West and co-workers from the University of Alberta have reported in an Nazarov cyclization study combining DFT and experiment to explain the diastereoselectivity.

 

 

JACS paper

Posted in Cascade Reactions, Methodology, Named Reactions, Nazarov cyclization | Leave a Comment »

Not just benzynes anymore: cyclohexyne and cylcopentyne

Posted by naturalproductman on October 7, 2014

Neil Garg and co-workers have reported in JACS on an annulation process involving cyclohexynes.

 

JACS paper

Posted in Cascade Reactions, Methodology | Leave a Comment »

Cascade metathesis towards humulanolides

Posted by naturalproductman on October 4, 2014

Chuang-Chuang Li and co-workers at the University of Science and Technology have reported in JACS on a cascade metathesis approach to the synthesis of humulanolides.

metathesis

JACS paper

Posted in Cascade Reactions, Humulanolides, Metathesis, Methodology | Leave a Comment »

NHC-catalyzed [4+2]

Posted by naturalproductman on October 4, 2014

David Lupton and co-worker at Monash University have reported in JACS on an NHC-catalyzed [4+2] reaction.
4+2

JACS paper

Posted in Carbene, Cascade Reactions, Methodology | Leave a Comment »

Fe-catalyzed cross coupling

Posted by naturalproductman on October 4, 2014

Eiichi Nakamura and co-workers at the University of Tokyo have reported in JACS on an iron catalyzed C-sp2-H to organoboron cross coupling reaction.

boron

JACS paper

Posted in C-H activation, Cascade Reactions, Iron, Methodology, Transition Metal | Leave a Comment »

Allenyl gold complexes

Posted by naturalproductman on September 8, 2014

Concepcion Gimeno and co-workers from ISQCH in Spain have reported in JACS on an allenyl gold complex. I wonder how they would react with electrophiles.

allenyl gold

JACS paper

Posted in Allenes, Gold, Methodology, Transition Metal | Leave a Comment »

Asymmetric metathesis

Posted by naturalproductman on September 8, 2014

Grubbs and colleagues have reported in JACS on their studies with asymmetric ring closing metathesis.

asymmetric

JACS paper

Posted in Asymmetric, Cascade Reactions, Metathesis, Methodology, Ring Opening | 1 Comment »

Towards plumarellide

Posted by naturalproductman on August 31, 2014

Gerald Pattenden and co-workers from the University of Nottingham in the UK have reported in Tetrahedron on a [4+2] approach to plumarellide.

4+2
Tetrahedron paper

Posted in Cascade Reactions, Methodology | 2 Comments »

Oxepanes via Ferrier

Posted by naturalproductman on August 31, 2014

Srinivasan Chandrasekaran and co-workers at the Indian Institute of Science have reported in Tetrahedron on a Ferrier rearrangement to form oxepanes.

 

Ferrier

Tetrahedron paper

Posted in Cascade Reactions, Ferrier, Methodology, Named Reactions, Ring expansion, Ring Opening | Leave a Comment »

 
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