Naturalproductman’s Blog

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Archive for the ‘Methodology’ Category

Rhodium cascade

Posted by naturalproductman on July 16, 2014

Richmond Sarpong and co-workers have reported in ACIE on a rhodium catalyzed cascade reaction involving an aza-Cope rearrangement.

Cope

ACIE paper

Posted in Aza-Cope rearrangement, Cascade Reactions, Methodology, Named Reactions, Rhodium, Transition Metal | Leave a Comment »

Claisen-Diels-Alder cascade to spirooliganones A and B

Posted by naturalproductman on July 16, 2014

Rongbiao Tong and co-workers from the Hong Kong University of Science and Technology have reported in Org Lett on a slick reaction to form spirooliganones.

 
spirooliganones

OL paper

Posted in Cascade Reactions, Claisen rearrangement, Diels-Alder, Methodology, Named Reactions, Total Synthesis | Leave a Comment »

Indole alkaloid synthesis

Posted by naturalproductman on July 15, 2014

Corey Stephenson and colleague at the University of Michigan have reported in JACS on the synthesis of pseudotabersonine. A mental roadblock for me was when I was looking at the paper, I was trying to find the structure of catalyst 5, which was the iridium catalyst used for a ring opening reaction, but just found the number 5 in the scheme. Within the text of the paper however it says Ir(dF(CF3)ppy)2(dtbbpy)PF6, which was cited with a Sigma Aldrich catalog number.

 

photoredox

JACS paper

Posted in Alkaloids, Indoles, Iridium, Light Mediated, Methodology, Transition Metal | Leave a Comment »

Crinipellin A synthesis

Posted by naturalproductman on July 12, 2014

Hee-Yoon Lee and co-workers at KAIST have reported in JACS on the synthesis of crinipellin A.

synthesis

JACS paper

Posted in Allenes, Methodology, Total Synthesis | Leave a Comment »

Tetrapetalone A-Me glycon synthesis

Posted by naturalproductman on July 12, 2014

Alison Frontier and co-workers at Rochester University and Hoveyda Boston College have reported in ACIE on the synthesis of tetrapetalone A-Me glycon.

tetrapetalone

 

ACIE paper

Posted in Alkaloids, Methodology, Named Reactions, Nazarov cyclization, Total Synthesis | Leave a Comment »

Gracilamine synthesis

Posted by naturalproductman on July 12, 2014

Shuanhu Gao and co-workers at East China Normal University have reported in ACIE on the synthesis of gracilamine.
alkaloid

ACIE paper

 

Posted in Alkaloids, Mannich, Methodology, Michael, Named Reactions, Nazarov cyclization, Total Synthesis | Leave a Comment »

Keteniminium cyclization

Posted by naturalproductman on June 30, 2014

Gwilherm Evano and co-workers from Université Libre de Bruxelles (ULB) in Belgium, have reported in JACS on a Bronstead acid catalyzed cyclization.

H+

JACS paper

Posted in Cascade Reactions, Methodology | Leave a Comment »

Ireland Claisen/Cope rearrangement

Posted by naturalproductman on June 30, 2014

James Leighton and co-workers reported in JACS on a mechanistic study of a tandem Ireland Claisen/Cope rearrangement reaction to form some polycyclic rings.

oxy Cope

JACS paper

Posted in Cascade Reactions, Claisen rearrangement, Cope rearrangement, Mechanistic, Methodology, Named Reactions, oxy-Cope rearrangement | Leave a Comment »

Marinomycin A synthesis

Posted by naturalproductman on June 28, 2014

Susumi Hatakeyama and co-workers from Nagasaki University have reported in ACIE on the synthesis of marinomycin A.

marinomycin A

ACIE paper

Posted in C2-Symmetric, Methodology, Polyketides, Total Synthesis | Leave a Comment »

Ileabethoxazole synthesis

Posted by naturalproductman on June 7, 2014

David Williams and colleague have reported in JACS on the synthesis of ileabethoxazole.

JACS paper

Posted in Asymmetric, Cascade Reactions, Methodology, Named Reactions, Pauson-Khand, Total Synthesis | Leave a Comment »

 
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