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Archive for the ‘C-H activation’ Category

Pd-catalyzed C-N bond formation

Posted by naturalproductman on June 5, 2014

Matthew Gaunt and co-workers from the University of Cambridge have reported in Nature on a palladium catalyzed intramolecular C-N bond formation from C-H bonds. I am reminded of the ACIE paper from Frances Arnold’s group at Caltech where they used a P450 mutant to do a similar reaction.

 

Nature paper

Posted in C-H activation, Methodology, Palladium, Transition Metal | Leave a Comment »

C-H activation within the ruthenium complex

Posted by naturalproductman on May 6, 2014

Another Houk collaboration – this time with Grubbs’ lab. They studied the mechanism of the carboxylate assisted C-H activation of the metathesis catalyst. The SDD basis set was used to approximate the orbitals of ruthenium in this report.

C-H

JACS paper

Posted in C-H activation, Computational, DFT, Methodology | Leave a Comment »

Silylation of C-H bonds

Posted by naturalproductman on May 6, 2014

I like this silylation of a C-H bond using an iridium catalyst. Very interesting from the lab of John Hartwig at Berkeley.

Ir

JACS paper

Posted in Asymmetric, C-H activation, Iridium, Methodology, Transition Metal | Leave a Comment »

C-H activation methodology

Posted by naturalproductman on March 13, 2014

How crazy is it that one research group publishes in Nature and Science in the SAME week?

 

Science paper

 

Nature paper

Posted in C-H activation, Methodology, Palladium, Transition Metal | Leave a Comment »

Podophyllotoxin synthesis

Posted by naturalproductman on February 19, 2014

Thomas Maimone and colleague have reported in ACIE on the synthesis of podophyllotoxin.

podophyllotoxin

ACIE paper

Posted in C-H activation, Methodology, Total Synthesis | Leave a Comment »

Maoecrystal V synthesis

Posted by naturalproductman on September 25, 2013

Armen Zakarian and co-workers have reported in JACS on a synthesis of maoecrystal V.

maoecrystal V

JACS paper

Posted in C-H activation, Methodology, Radical Chemistry, Total Synthesis | Leave a Comment »

Rhodium-catalyzed C-H amination

Posted by naturalproductman on September 5, 2013

Justin DuBois and co-workers have reported in ACIE on a C-H activation approach to introducing C-N bonds.

C-H

ACIE paper

Posted in C-H activation, Methodology, Rhodium, Transition Metal | Leave a Comment »

C-P bond from a C-H bond

Posted by naturalproductman on July 24, 2013

Masahiro Murakami and co-workers have reported in ACIE on a C-P bond formation.

C-H

ACIE paper

Posted in C-H activation, Methodology, Palladium, Transition Metal | Leave a Comment »

C-H activation

Posted by naturalproductman on July 24, 2013

Nobuharu Iwasawa and co-workers at Tokyo Institute of Technology have reported in JACS on a palladium catalyzed CO2 fixation reaction to form coumarins from a vinyl phenol.

coumarin

JACS paper

Posted in C-H activation, Methodology, Palladium, Transition Metal | Leave a Comment »

C-H activation with phthaloyl peroxide

Posted by naturalproductman on July 11, 2013

Dionicio Siegel and co-workers at UT Austin have reported in Nature on the use of phthaloyl peroxide for a C-H activation reaction.

 

Nature paper

Posted in C-H activation, Methodology | Leave a Comment »

 
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