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Archive for the ‘C-H activation’ Category

Fe-catalyzed cross coupling

Posted by naturalproductman on October 4, 2014

Eiichi Nakamura and co-workers at the University of Tokyo have reported in JACS on an iron catalyzed C-sp2-H to organoboron cross coupling reaction.

boron

JACS paper

Posted in C-H activation, Cascade Reactions, Iron, Methodology, Transition Metal | Leave a Comment »

Scandium-catalyzed hydroarylation

Posted by naturalproductman on August 30, 2014

Zhaomin Hou and co-workers from RIKEN have reported in JACS on an enantioselective hydroarylation using a scandium complex.
Sc

JACS paper

Posted in C-H activation, Methodology, Scandium, Transition Metal | Leave a Comment »

Steviol, hetidine, isoatisine syntheses

Posted by naturalproductman on August 30, 2014

Phil Baran and co-workers have reported in JACS on the syntheses of steviol, hetidine, and isoatisine.

alkaloids

JACS paper

Posted in Alkaloids, C-H activation, Methodology, Total Synthesis | Leave a Comment »

Pd-catalyzed C-N bond formation

Posted by naturalproductman on June 5, 2014

Matthew Gaunt and co-workers from the University of Cambridge have reported in Nature on a palladium catalyzed intramolecular C-N bond formation from C-H bonds. I am reminded of the ACIE paper from Frances Arnold’s group at Caltech where they used a P450 mutant to do a similar reaction.

 

Nature paper

Posted in C-H activation, Methodology, Palladium, Transition Metal | Leave a Comment »

C-H activation within the ruthenium complex

Posted by naturalproductman on May 6, 2014

Another Houk collaboration – this time with Grubbs’ lab. They studied the mechanism of the carboxylate assisted C-H activation of the metathesis catalyst. The SDD basis set was used to approximate the orbitals of ruthenium in this report.

C-H

JACS paper

Posted in C-H activation, Computational, DFT, Methodology | Leave a Comment »

Silylation of C-H bonds

Posted by naturalproductman on May 6, 2014

I like this silylation of a C-H bond using an iridium catalyst. Very interesting from the lab of John Hartwig at Berkeley.

Ir

JACS paper

Posted in Asymmetric, C-H activation, Iridium, Methodology, Transition Metal | Leave a Comment »

C-H activation methodology

Posted by naturalproductman on March 13, 2014

How crazy is it that one research group publishes in Nature and Science in the SAME week?

 

Science paper

 

Nature paper

Posted in C-H activation, Methodology, Palladium, Transition Metal | Leave a Comment »

Podophyllotoxin synthesis

Posted by naturalproductman on February 19, 2014

Thomas Maimone and colleague have reported in ACIE on the synthesis of podophyllotoxin.

podophyllotoxin

ACIE paper

Posted in C-H activation, Methodology, Total Synthesis | Leave a Comment »

Maoecrystal V synthesis

Posted by naturalproductman on September 25, 2013

Armen Zakarian and co-workers have reported in JACS on a synthesis of maoecrystal V.

maoecrystal V

JACS paper

Posted in C-H activation, Methodology, Radical Chemistry, Total Synthesis | Leave a Comment »

Rhodium-catalyzed C-H amination

Posted by naturalproductman on September 5, 2013

Justin DuBois and co-workers have reported in ACIE on a C-H activation approach to introducing C-N bonds.

C-H

ACIE paper

Posted in C-H activation, Methodology, Rhodium, Transition Metal | Leave a Comment »

 
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