Carlos Saa and co-workers at Universidad de Santiago de Compostela have reported in ACIE on a reaction involving a ruthenium cascade followed by C-O formation to form dihydropyrans.
Archive for the ‘Carbene’ Category
Posted by naturalproductman on October 16, 2012
Cheol-Min Park and co-workers at Nanyang Technological University have reported in Chem Comm on a method for synthesis of pyridines through N-O bond cleavage using a carbenoid precursor.
Posted by naturalproductman on March 29, 2012
Claude Spino and co-workers at Universite de Sherbrooke have reported in JACS on a [4+1] cascade. A loss of a diazo group involved, hmm…reminds me of some of Dale Boger’s work.
Posted by naturalproductman on February 29, 2012
Duncan Wardrop and co-worker from the University of Illinois in Chicago have reported in Organic Letters on an interesting approach to form a carbene by presumably forming a tetraazafulvene intermediate, which breaks down to the carbene by losing two molecules of nitrogen (ie: N2). At first I wondered how scary this reaction is because of the gain of entropy, but it looks pretty straight forward: they just add DIC (diisopropylcarbodiimide) to the tetrazole and then load the reaction mixture directly on a column for purification.
Posted by naturalproductman on February 21, 2012
Jianwei Sun and co-workers at Hong Kong University of Science and Technology have reported in Organic Letters on a carbene catalyzed formation of allenoates.