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Archive for the ‘Cascade Reactions’ Category

multiple reactions back to back (to back) in one go

Corynoxine synthesis

Posted by naturalproductman on December 18, 2014

Chengfeng Xia and co-workers from the Chinese Academy of Sciences have reported in JACS on the syntheses of corynoxine.

corynoxine

JACS paper

Posted in Alkaloids, Cascade Reactions, Spirocycles, Total Synthesis | Leave a Comment »

Dibromoalkenes from alkynes

Posted by naturalproductman on November 29, 2014

Weimin He and co-workers from Hunan University have reported in JOC on the synthesis of E-dibromoalkenes from alkynes using CuBr2.
copper

JOC paper

Posted in Cascade Reactions, Copper, Methodology, Transition Metal | Leave a Comment »

Propargylamines via multi-component approach

Posted by naturalproductman on November 29, 2014

Zhihua Sun and co-workers from the Shanghai University of Engineering Science have reported in JOC on a multicomponent approach to substituted propargylamines.

MCC

JOC paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling | Leave a Comment »

Pyridinium leaving group

Posted by naturalproductman on November 29, 2014

Philip Albiniak and colleagues at Ball State University have reported in Tetrahedron Letters on the synthesis of tert-butyl ethers using a pyridinium leaving group.

tertbutyl

TL paper

Posted in Cascade Reactions, Methodology | 1 Comment »

Multi-component coupling with cobalt

Posted by naturalproductman on November 28, 2014

Xiaobing Wan and co-workers from Soochow University have reported in ACIE on a multi-component coupling approach to access β-Ester-γ-amino ketones.

tbhp

ACIE paper

Posted in Cascade Reactions, Cobalt, Methodology, Multi-Component Coupling, Transition Metal | Leave a Comment »

4-Hydroxycyclopentenones from furans

Posted by naturalproductman on November 16, 2014

Javier Read de Alaniz and co-workers from UCSB have reported in Tetrahedron Letters on the synthesis of cyclopentenones from furans through a Piancatelli rearrangement.
Piancatelli
TL paper

Posted in Cascade Reactions, Methodology, Named Reactions, Piancatelli rearrangement, Ring Opening | 1 Comment »

Thioalkynes from hypervalent iodine

Posted by naturalproductman on November 14, 2014

Jerome Waser and colleagues at EPFL have reported in JACS on a way to synthesize thioalkynes from hypervalent iodine.

iodine

JACS paper

Posted in Cascade Reactions, Methodology, Sulfur chemistry | 1 Comment »

Depolymerization of oxidized lignins

Posted by naturalproductman on November 13, 2014

Shannon Stahl and co-workers have reported in Nature on a depolymerization process of oxidized lignins induced by formic acid.

 

Nature paper

Posted in Cascade Reactions, Depolymerization, Methodology | Leave a Comment »

Difluorination using hypervalent iodine

Posted by naturalproductman on November 10, 2014

Kálmán J. Szabó and co-workers from Stockholm University have reported in ACIE on a difluorination of styrene using a hypervalent iodide reagent.

fluorination
ACIE paper

Posted in Cascade Reactions, Hypervalent Iodine, Methodology | Leave a Comment »

Pyridines from aziridines

Posted by naturalproductman on November 10, 2014

Masahiro Yoshida and co-workers from the University of Tokushima have reported in ACIE on the synthesis of pyridines from aziridines.

pyridine

ACIE paper

Posted in Cascade Reactions, Methodology | Leave a Comment »

 
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