Naturalproductman’s Blog

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Archive for the ‘Chemoselective’ Category

Mask the More Reactive Carbonyl

Posted by naturalproductman on November 3, 2010

David Colby and co-workers from Purdue have just added a useful way to selectively reduce less reactive carbonyls (ie: lactone) over more reactive ones (ie:  ketone) by introducing N,O-dimethylhydroxylamine in the presence of an aluminum reducing agent (DIBAL).

selective reduction

 

OL paper

Posted in Chemoselective, Methodology | Leave a Comment »

 
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