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Archive for the ‘cross coupling’ Category

Metal Catalyzed Cross Coupling Reactions

Aryl halide couplings with Sp3-carbons

Posted by naturalproductman on July 27, 2014

Gary Molander and colleagues reported in Science on a photoredox nickel dual catalysis for a cross coupling reaction between an sp3-hybridized organoboron and an aryl halide.

Science paper (Molander)

In the same issue, David Macmillan and co-workers have reported on a photoredox reaction involving a nickel catalyzed coupling between an sp3-alpha-carboxyl and an aryl halide.

Science paper (Macmillan)

 

Posted in Cascade Reactions, cross coupling, Light Mediated, Methodology, Nickel, Transition Metal | Leave a Comment »

Silyl Heck reaction

Posted by naturalproductman on August 30, 2013

Donald Watson and colleague have reported in JACS on silyl Heck variant.

vinyl silyl ethers

JACS paper

Posted in cross coupling, Heck, Methodology, Palladium, Transition Metal | Leave a Comment »

Towards PF-1018

Posted by naturalproductman on April 2, 2013

Dirk Trauner and co-workers at have reported in Organic Letters on a Stille-Diels Alder cascade approach towards PF-1018.

PF-1018

OL paper

Posted in Cascade Reactions, cross coupling, Diels-Alder, Methodology, Named Reactions, Stille | Leave a Comment »

Ullman with light

Posted by naturalproductman on November 2, 2012

I guess Greg Fu made a statement at Caltech with his Science paper in collaboration with the Jonas Peters group. This Science paper discloses an Ullman reaction (copper mediated aryl iodide and amine coupling) in the presence of light.

 

Science paper

Posted in Copper, cross coupling, Light Mediated, Methodology, Transition Metal, Ullmann | Leave a Comment »

Mizoroki-Heck reaction

Posted by naturalproductman on October 25, 2012

Janine Cossy and co-workers from CNRS have reported in Organic Letters on a palladium catalyzed approach to access trienols.

trienol

OL paper

Posted in cross coupling, Methodology, Mizoroki-Heck, Palladium, Transition Metal | Leave a Comment »

Myxalamide synthesis

Posted by naturalproductman on June 21, 2012

Susumu Kobayashi and co-workers at the Tokyo University of Science have reported in ACIE on the synthesis of myxalamide.

myxalamide

ACIE paper

Posted in Alkaloids, cross coupling, Methodology, Polyenes | Leave a Comment »

A Heck reaction for a seven membered ring

Posted by naturalproductman on June 11, 2012

Silas Cook and colleague at Indiana University have reported in Organic Letters on a formal synthesis of englerin.
englerin

OL paper

Posted in cross coupling, Heck, Methodology, Sesquiterpenoids, Seven-Membered Rings | Leave a Comment »

NHK coupling asymmetrically

Posted by naturalproductman on March 29, 2012

The Nozaki-Hiyama-Kishi coupling couples an a R-halide group with an aldehyde.  Kishi and co-workers have reported on a catalytic, asymmetric version in JACS recently.
NHK

JACS paper

Posted in Asymmetric, Chromium, cross coupling, Methodology, Named Reactions, Nickel, Nozaki-Hiyama-Kishi, Transition Metal | Leave a Comment »

Click cascade

Posted by naturalproductman on February 23, 2012

Qian Cai and co-workers from Guanzhou Institutes of Biomedicine and Health have reported in Organic Letters on a click reaction followed by cross coupling.

click

OL paper

Posted in Cascade Reactions, Copper, cross coupling, Methodology, Transition Metal | 2 Comments »

Trifluoromethylation of vinyltrifluoroborates

Posted by naturalproductman on February 21, 2012

Buchwald and co-workers have reported in ACIEE on an iron catalyzed trifluoromethylation of vinyltrifluoroborates.

boronates

ACIEE paper

Posted in Cascade Reactions, cross coupling, Iron, Methodology, Transition Metal | Leave a Comment »

 
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