A Heck reaction for a seven membered ring

Silas Cook and colleague at Indiana University have reported in Organic Letters on a formal synthesis of englerin.

OL paper

Daphmanidin synthesis

Erick Carreira and co-worker have reported in ACIEE on the synthesis of daphmanidin.

ACIEE paper

Oxidative Heck

Hequan Yao and co-workers from China Pharmaceutical University have reported in Tetrahedron Letters on a palladium catalyzed oxidative Heck coupling.

TL paper

Allyl alcohol transformation

Jianliang Xiao and co-workers at the University of Liverpool have reported in Organic Letters on a one pot transformation of an allyl alcohol substrate to access dihydrochalcones.

OL paper

Aspidophylline synthesis

Neil Garg and co-workers from UCLA have reported in JACS on their synthesis of aspidophylline where the key reaction was an interrupted Fischer indolization.

JACS paper

Crinine Synthesis

Xiaodong Yang and co-workers at Yunnan University have published in Synlett on their formal synthesis of crinine.  The seven membered ring with an exocyclic methylene was synthesized by an intramolecular Heck reaction.

 

Synlett paper

Palladium/Copper Catalyzed Multi-Component Cascade

Junliang Zhang and co-worker published in Chem Comm again on a three component coupling approach to synthesize tetrasubstituted furans.

Chem Comm paper

Carbonylative Heck

Erik Alexanian and co-worker at the University of North Carolina at Chapel Hill have published in JACS on a carbonylative Heck reaction using palladium tetrakis(triphenyl)phosphine as the catalyst.  This reaction works best with non-polar solvents such as toluene because of a possible formation of phosphonium salts in polar solvents (THF:ACN).

JACS paper

Synthesis of Rhazinilam

Armen Zakarian and co-worker have published in UCSB on a Heck cyclization approach to access rhazinilam.

OL paper

A Heck Coupling

Marco Ciofulini and co-workers at the University of British Columbia have published in Chemical Communications on a Pd catalyzed Csp2 carbon-aryl carbon bond forming process – ie:  Heck coupling – to form homotyrosine derivatives.

Chem Comm paper