Terreusinone synthesis

Jonathan Sperry and colleague at the University of Auckland have reported in Organic Letters on a synthesis of terreusinone.

OL paper

MCC with Sonogashira

Matthius Beller and co-workers at Universitat Rostock
Albert-Einstein-Strasse have reported in ACIEE on a palladium catalyzed carbonylative Sonogashira coupling.

ACIEE paper

Deshydroxyajudazol B Synthesis

Mark Rizzacasa and co-workers at the University of Melbourne have reported in Organic Letters on the synthesis of dehydroxyajudazol B.

 

OL paper

Sonogashira without Copper

Hideaki Wakamatsu and co-workers at Tohoku Pharmaceutical University have published in Synlett on a Sonogashira coupling reaction without the use of copper.

Synlett paper

Smiles Rearrangement Followed by Sonogashira-Cyclization Cascade

Roberto Sanz and co-workers from Universidad de Burgos have published in Organic and Biomolecular Chemistry on a method to access indole rings starting from phenylcarbamates.  The nitrogen of the indole ring is introduced via Smiles rearrangement of the carbamate-protected phenol to exchange the oxygen to nitrogen.

OBC paper

Pd-Catalyzed Intermolecular Cyclization Cascade

Chinmay Chowdhury and co-workers at CSIR have recently reported in Tetrahedron Letters on a tandem cyclization cascade reaction.

Tetrahedron Letters paper

Sonogashira Cascade

Ali Keivanloo and co-workers from Shahrood University of Technology have recently published in Synthesis on a Sonogashira reaction followed by heteroannulation to form pyrrolo[2,3-b]quinoxaline-
2-carbaldehydes.

Synthesis paper

TL paper

Substituted Quinoline Synthesis

Yuefa Gong and co-workers at Huazhong University of Science and Technology have recently published in Chem Comm on a cascade Sonogashira cyclization process that led to substituted quinolines.

Chem Comm paper

Iodophenol + Terminal Alkyne = Benzofuran

Kristin Price and co-workers at Pfizer have recently published in Organic Process Research and Development on a nice Sonogashira coupling of a terminal alkyne with an iodo-phenol compound that subsequently cyclizes to form benzofuran compounds.

OPR&D paper

Synthesis of Mersicarpine

Fukuyama and co-workers at the University of Tokyo have recently reported on a synthesis of mersicarpine.  A highlight of the synthesis includes a coupling between a haloaniline with an alkyne to form the indole moiety.  In addition, the Eschenmoser-Tanabe fragmentation to afford the alkyne fragment was pretty neat.

JACS paper