Naturalproductman’s Blog

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Archive for the ‘Enzymatic’ Category

Selective macrocyclization

Posted by naturalproductman on April 23, 2012

Christopher Boddy and co-workers at the University of Ottawa have reported in Organic Letters on the selective macrocyclization using DEBS TE.

enzyme

OL paper

Posted in Chemical Biology, Enzymatic, Macrocycles, Macrolides, Methodology | Leave a Comment »

Diepoxide intermediate

Posted by naturalproductman on April 20, 2012

Hideaki Oikawa and co-workers at Hokkaido University have reported in JACS on a sequential epoxidation of a bis olefin compound to yield a diepoxide that undergoes a ring opening cascade to form two cyclic polyethers (a tetrahydropyran and tetrahydrofuran).

epoxidation

JACS paper

Posted in Biosynthesis, Carboxylic acids, Chemical Biology, Enzymatic, Methodology | Leave a Comment »

Heparin’s chemoenzymatic synthesis

Posted by naturalproductman on October 28, 2011

Jian Liu and co-workers at UNC have reported in Science on a chemoenzymatic synthesis of the sulfated glycan, heparin – a blood thinner.

 

Science paper

Posted in Chemical Biology, Enzymatic, Glycosides, Methodology | Leave a Comment »

Clividine synthesis

Posted by naturalproductman on July 27, 2011

Martin Banwell and co-workers at the Australian National University have reported in JOC on their synthesis of clividine.

clividine

JOC paper

Posted in Alkaloids, Enzymatic, Methodology | Leave a Comment »

C-C bond forming process using an enzyme

Posted by naturalproductman on July 5, 2011

Claudia Schmidt-Dannert and colleague at the University of Minnesota have reported in ACIEE on the use of BBE (berberine bridge enzyme) to selectively form a C-C bond.

enzyme

ACIEE paper

Posted in Enzymatic, Methodology, Unnatural Products | Leave a Comment »

Hydroxymethylcytosine

Posted by naturalproductman on June 19, 2011

Thomas Carrel and co-workers from Ludwig-Maximilians University in Munich have published a mini-review on hydroxymethylcytosine, a newly discovered modification of DNA – as if methylating cytosine was not enough.

DNA

ACIEE paper

Posted in Chemical Biology, Enzymatic, Proteins | Leave a Comment »

A new C35-terpene cyclase

Posted by naturalproductman on June 7, 2011

Tsutomu Sato and co-workers from Niigata University have reported in JACS on the identification of a terpene cyclase enzyme that cyclized a C35 terpene (sesquarterpene).

C35

JACS paper

Posted in Chemical Biology, Enzymatic, Methodology, Sesquarterpenes, Terpenes | Leave a Comment »

Borrelidin studies

Posted by naturalproductman on June 5, 2011

Sabine Laschat and co-workers from the Universitat Stuttgart have reported in European JOC on their studies towards borrelidin where they used CYP102A to perform a regioselective hydroxylation of an alkane.

chemoenzymatic
European JOC paper

Posted in Asymmetric, Enzymatic, Methodology | Leave a Comment »

Allenes from alkynes biosynthetically

Posted by naturalproductman on May 24, 2011

Georg Pohnert and co-workers from Friedrich Schiller University have reported in Organic Letters on the biosynthesis of a conjugated allene found in the biosynthetic pathway of moss Dicranum scoparium.
allene
OL paper

Posted in Allenes, Biosynthesis, Enzymatic, Methodology | Leave a Comment »

Valproic Acid Monitoring

Posted by naturalproductman on March 6, 2011

Renato Zenobi and colleagues at ETH Zurich have reported in Chem Comm on a way to detect the pharmacokinetics of valproic acid, a drug used to treat epilepsy.

valproic acid

Chem Comm paper

Posted in Chemical Biology, Enzymatic, Metabolomics, Methodology, New Setups, Pharmacokinetics | Leave a Comment »

 
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