Naturalproductman’s Blog

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Archive for the ‘Hydride Shift’ Category

Arabilin synthesis

Posted by naturalproductman on December 2, 2011

Kathlyn Parker and colleague have reported in JACS on a synthesis of arabilin, an androgen receptor antagonist that can potentially treat prostate cancer (IC50 of 11 micromolar towards AR).  A 1,7-hydride shift occured in their key Stille coupling to afford the correct isomer.

antagonist

JACS paper

Posted in Cancer, Cascade Reactions, cross coupling, Hydride Shift, Methodology, prostate, Protein Targets, Proteins, Receptors, Stille, Transition Metal | Leave a Comment »

Hydride Shift and Hydride Shift

Posted by naturalproductman on February 18, 2011

Takahiko Akiyama and co-workers at Gakushuin University have reported in JACS on a carbon-carbon bond cleaving process followed by a carbon-carbon bond forming process using a scandium (III) triflate catalyst.

C-H

JACS paper

Posted in Cascade Reactions, Hydride Shift, Methodology, Ring forming, Scandium, Transition Metal | Leave a Comment »

 
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