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Archive for the ‘Hypervalent Iodine’ Category

Difluorination using hypervalent iodine

Posted by naturalproductman on November 10, 2014

Kálmán J. Szabó and co-workers from Stockholm University have reported in ACIE on a difluorination of styrene using a hypervalent iodide reagent.

fluorination
ACIE paper

Posted in Cascade Reactions, Hypervalent Iodine, Methodology | Leave a Comment »

Phenolic coupling for morphine

Posted by naturalproductman on November 10, 2014

Matthew Gaunt and co-workers from the University of Cambridge have reported in ACIE on the formal synthesis of morphine through an oxidative phenolic coupling.

morphine

ACIE paper

Posted in Alkaloids, Cascade Reactions, Hypervalent Iodine, Methodology, Total Synthesis | Leave a Comment »

Aspeverin synthesis

Posted by naturalproductman on August 30, 2014

Adam Levinson at Sloan Kettering has reported in Organic Letters on the synthesis of aspeverin. Interestingly, Danishefsky was acknowledged for the mentorship but not included in the authors list. I wonder if this is a new kind of way to publish.

aspeverin

OL paper

Posted in Alkaloids, Hypervalent Iodine, Methodology, Total Synthesis | 3 Comments »

Hypervalent iodine promoted aryl shift

Posted by naturalproductman on May 10, 2013

Thomas Wirth and co-workers at Cardiff University have reported in ACIE on a hypervalent iodine reagent promoted migration of an aryl group.

iodine

ACIE paper

Posted in Asymmetric, Hypervalent Iodine, Methodology | Leave a Comment »

Trifluoromethylation with hypervalent iodide

Posted by naturalproductman on February 20, 2012

Zhiqiang Weng and co-workers from Fuzhou University have reported in Tetrahedron on the use of a hypervalent iodide to introduce a trifluoromethyl group on the terminal position of an alkyne.

hypervalent iodide

Tetrahedron paper

Posted in Hypervalent Iodine, Methodology | 2 Comments »

Chiral Hypervalent Iodide

Posted by naturalproductman on February 16, 2012

Morifumi Fujita and co-workers at the University of Hyogo have reported in Organic Letters on the use of a chiral hypervalent iodine reagent

hypervalent iodide

OL paper

Posted in Asymmetric, Cascade Reactions, Hypervalent Iodine, Methodology, Polyketides | Leave a Comment »

Oxyamination

Posted by naturalproductman on February 10, 2012

Thomas Wirth and co-worker from Cardiff University have reported in ACIEE on the use of hypervalent iodine to effect an oxyamination.

oxyamination
ACIEE paper

Posted in Hypervalent Iodine, Methodology | Leave a Comment »

Welwitindolinone C syntheses

Posted by naturalproductman on January 11, 2012

The Rawal and Garg groups published in JACS independently on their syntheses of welwitindolinone C back to back…Garg’s group used a deuterium isotope effect to improve the selectivity in the key C-N bond forming reaction.

alkaloid

JACS paper

deuterium

JACS paper

Posted in Alkaloids, C-H activation, Hypervalent Iodine, Methodology, Silver, Transition Metal | Leave a Comment »

Acyloxylation with gold

Posted by naturalproductman on October 31, 2011

Veronique Michelet and co-workers at CNRS have reported in JACS on a gold catalyzed C-H activation process.
gold

JACS paper

Posted in C-H activation, Gold, Hypervalent Iodine, Methodology, Transition Metal | Leave a Comment »

Olefin oxidation with iodosyl benzene

Posted by naturalproductman on October 22, 2011

Jose Barluenga and co-workers from the Universidad de Oviedo have reported in JACS on an iodosyl benzene mediated oxidation of an olefin to afford beta-diazocarbonyl compounds.

copper

JACS paper

Posted in Cascade Reactions, Copper, Hypervalent Iodine, Methodology, Transition Metal | Leave a Comment »

 
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