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Archive for the ‘Kinetic resolution’ Category

Posted by naturalproductman on March 7, 2014

Tsutomu Katsuki and co-workers at Kyushu University have reported on a ruthenium catalyzed kinetic resolution of racemic secondary alcohols via oxidation.

ruthenium

ACIE paper

Posted in Asymmetric, Kinetic resolution, Methodology, Ruthenium, Transition Metal | Leave a Comment »

KR by NHC

Posted by naturalproductman on July 24, 2013

Kenichi Yamada and co-workers at Kyoto University have reported in JACS on a kinetic resolution approach to resolve 1,2-diols.
NHC

JACS paper

Posted in Asymmetric, Kinetic resolution, Methodology, Organocatalytic | Leave a Comment »

DYKAT

Posted by naturalproductman on May 9, 2013

Jeffrey Johnson and co-workers at UNC have reported in Org Lett on a dynamic kinetic resolution.

KR

OL paper

Posted in Asymmetric, Friedel-Crafts, Kinetic resolution, Methodology, Named Reactions | Leave a Comment »

Determination of stereochemistry on a small scale

Posted by naturalproductman on December 5, 2012

Scptt Rychnovsky and co-workers have reported in JACS on a clever way to determine the stereochemical configuration of a primary amine by using mass spectrometry.  This may be useful when you only have a small amount of material.

chirality

JACS paper

Posted in Asymmetric, Kinetic resolution, Mass Spectrometry, Methodology | Leave a Comment »

Deracemization via ketene dithioacetal intermediate

Posted by naturalproductman on October 30, 2012

Benjamin List and colleague have reported in JACS on a deracemization reaction taking advantage of a ketene-dithioacetal intermediate.

ketene

JACS paper

Posted in Asymmetric, Kinetic resolution, Methodology, Organocatalytic | Leave a Comment »

DKR of alpha-keto esters

Posted by naturalproductman on April 19, 2012

Jeffrey Johnson and co-workers from UNC have reported in JACS on a dynamic kinetic resolution of substituted alpha-keto esters.

alpha keto ester

JACS paper

Posted in Asymmetric, Cascade Reactions, Kinetic resolution, Methodology | Leave a Comment »

Kinetic resolution with amidine

Posted by naturalproductman on February 10, 2012

Vladimir Birman and co-workers at Washington University in St. Louis have reported in JOC on a kinetic resolution of secondary alcohols using an amidine catalyst.

KR
JOC paper

Posted in Asymmetric, Kinetic resolution, Methodology | Leave a Comment »

Putaminoxin synthesis

Posted by naturalproductman on January 25, 2012

Biswanath Das and co-workers at Indian Institute of Chemical Technology have reported in the European Journal of Organic Chemistry on the synthesis of

putaminoxin

European JOC paper

Posted in Kinetic resolution, Macrolides, Methodology | Leave a Comment »

Portentol via Prins

Posted by naturalproductman on December 2, 2011

Pierre van de Weghe and co-workers at Université de Rennes have reported in Organic Letters on their progress towards portentol using a Prins reaction.

portentol

OL paper

 

Posted in Cascade Reactions, Kinetic resolution, Methodology, Named Reactions, Polyketides, Prins | Leave a Comment »

Kinetic resolution with NHC

Posted by naturalproductman on November 21, 2011

Jeffrey Bode and co-workers at ETH Zurich have reported in JACS on a kinetic resolution of cyclic secondary amides using N-heterocyclic carbenes as an organocatalyst.

resolution

JACS paper

Posted in Asymmetric, Cascade Reactions, Kinetic resolution, Methodology, Organocatalytic | Leave a Comment »

 
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