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Archive for the ‘Metathesis’ Category

Cochliomycin synthesis via NHK

Posted by naturalproductman on November 29, 2014

Martin Banwell and co-workers at the Australian National University have reported in JOC on the synthesis of cochliomycins A and B.

cochliomycins

JOC paper

Posted in cross coupling, Macrolides, Metathesis, Methodology, Named Reactions, Polyketides, Total Synthesis | Leave a Comment »

Neopeltolide through metathesis

Posted by naturalproductman on November 8, 2014

Hoveyda and co-workers have reported in ACIE on the synthesis of neopeltolide.

metathesis

ACIE paper

Posted in Metathesis, Methodology, Ruthenium, Total Synthesis, Transition Metal | Leave a Comment »

Disorazole through cross metathesis

Posted by naturalproductman on November 8, 2014

Hoveyda and co-workers from Boston College have reported in JACS on a Z-selective cross coupling to access this C2-symmetric molecule – using alkenyl boronate and alkenyl iodide moieties.
metathesis

JACS paper

Posted in Alkaloids, C2-Symmetric, Metathesis, Methodology, Oxazoles, Ruthenium, Transition Metal | Leave a Comment »

Cascade metathesis towards humulanolides

Posted by naturalproductman on October 4, 2014

Chuang-Chuang Li and co-workers at the University of Science and Technology have reported in JACS on a cascade metathesis approach to the synthesis of humulanolides.

metathesis

JACS paper

Posted in Cascade Reactions, Humulanolides, Metathesis, Methodology | Leave a Comment »

Asymmetric metathesis

Posted by naturalproductman on September 8, 2014

Grubbs and colleagues have reported in JACS on their studies with asymmetric ring closing metathesis.

asymmetric

JACS paper

Posted in Asymmetric, Cascade Reactions, Metathesis, Methodology, Ring Opening | 1 Comment »

Z-selective olefin metathesis

Posted by naturalproductman on August 20, 2014

Robert Grubbs and co-workers have reported in JACS on factors that influence Z-selective olefin metathesis.

Z-selective

JACS paper

Posted in Metathesis, Methodology, Ring forming, Ruthenium, Transition Metal | Leave a Comment »

WF-1360F synthesis

Posted by naturalproductman on April 23, 2013

Karl-Heinz Altmann and co-workers at have reported in ACIE on the synthesis of WF-1360F.

WF-1360F

ACIE paper

Posted in Macrolides, Metathesis, Methodology, Total Synthesis | Leave a Comment »

Spirangien A synthesis

Posted by naturalproductman on January 17, 2013

Mark Rizzacasa and co-workers from the University of Melbourne have reported in Organic Letters on their formal synthesis of spirangien A.

spirangien A

OL paper

Posted in Iron, Manganese, Metathesis, Methodology, Polyketides, Spiroketals, Transition Metal | Leave a Comment »

FD-895 synthesis

Posted by naturalproductman on October 25, 2012

Michael Burkart and James J. La Clair and colleagues at UCSD have reported in Org Lett on the synthesis of

synthesis
OL paper

Posted in Macrolides, Metathesis, Methodology, Polyketides, Ring forming, Ruthenium, Structural Reassignment, Transition Metal | Leave a Comment »

Enyne metathesis

Posted by naturalproductman on August 6, 2012

Steven Diver and co-workers from the University of Buffalo have reported in Organic Letters on an enyne metathesis reaction.

metathesis

OL paper

Posted in Cascade Reactions, Metathesis, Methodology | Leave a Comment »

 
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