Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for the ‘Metathesis’ Category

Cascade metathesis towards humulanolides

Posted by naturalproductman on October 4, 2014

Chuang-Chuang Li and co-workers at the University of Science and Technology have reported in JACS on a cascade metathesis approach to the synthesis of humulanolides.

metathesis

JACS paper

Posted in Cascade Reactions, Humulanolides, Metathesis, Methodology | Leave a Comment »

Asymmetric metathesis

Posted by naturalproductman on September 8, 2014

Grubbs and colleagues have reported in JACS on their studies with asymmetric ring closing metathesis.

asymmetric

JACS paper

Posted in Asymmetric, Cascade Reactions, Metathesis, Methodology, Ring Opening | 1 Comment »

Z-selective olefin metathesis

Posted by naturalproductman on August 20, 2014

Robert Grubbs and co-workers have reported in JACS on factors that influence Z-selective olefin metathesis.

Z-selective

JACS paper

Posted in Metathesis, Methodology, Ring forming, Ruthenium, Transition Metal | Leave a Comment »

WF-1360F synthesis

Posted by naturalproductman on April 23, 2013

Karl-Heinz Altmann and co-workers at have reported in ACIE on the synthesis of WF-1360F.

WF-1360F

ACIE paper

Posted in Macrolides, Metathesis, Methodology, Total Synthesis | Leave a Comment »

Spirangien A synthesis

Posted by naturalproductman on January 17, 2013

Mark Rizzacasa and co-workers from the University of Melbourne have reported in Organic Letters on their formal synthesis of spirangien A.

spirangien A

OL paper

Posted in Iron, Manganese, Metathesis, Methodology, Polyketides, Spiroketals, Transition Metal | Leave a Comment »

FD-895 synthesis

Posted by naturalproductman on October 25, 2012

Michael Burkart and James J. La Clair and colleagues at UCSD have reported in Org Lett on the synthesis of

synthesis
OL paper

Posted in Macrolides, Metathesis, Methodology, Polyketides, Ring forming, Ruthenium, Structural Reassignment, Transition Metal | Leave a Comment »

Enyne metathesis

Posted by naturalproductman on August 6, 2012

Steven Diver and co-workers from the University of Buffalo have reported in Organic Letters on an enyne metathesis reaction.

metathesis

OL paper

Posted in Cascade Reactions, Metathesis, Methodology | Leave a Comment »

Englerin A formal synthesis

Posted by naturalproductman on May 7, 2012

Kathlynn Parker and colleague have reported in Organic Letters on a formal synthesis of englerin A.

englerin

OL paper

Posted in Cascade Reactions, Metathesis, Methodology, Ruthenium, Sesquiterpenoids, Transition Metal | Leave a Comment »

Fluorous mixture synthesis application

Posted by naturalproductman on May 1, 2012

Dennis Curran and co-workers at the University of Pittsburgh have applied fluorous mixture synthesis to assign the stereochemistry of a macrolide.  Fluorous mixture synthesis is a technique where they install fluorinated tag protecting groups on the alcohols where each tag varies by the number of fluorines.  They are able to separate the tagged compounds based on the number of flourines on the tags.

fluorous

JACS paper

Science paper

Posted in Macrolides, Metathesis, Methodology, Ruthenium, Total Synthesis, Transition Metal | Leave a Comment »

Oxyingenol synthesis

Posted by naturalproductman on April 17, 2012

Hideo Kigoshi and co-workers from the University of Tsukuba have reported in ACIE on the synthesis of oxyingenol.

oxyingenol

ACIE paper

Posted in Diseases, Diterpenoids, HIV, Metathesis, Methodology, Ruthenium, Sigmatropic Rearrangements, Total Synthesis, Transition Metal | Leave a Comment »

 
Follow

Get every new post delivered to your Inbox.

Join 72 other followers