Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for the ‘Multi-Component Coupling’ Category

This reaction involves combining more than two fragments together to form one large fragment.

Alpha-arylation/N-Alkylation

Posted by naturalproductman on December 17, 2013

Daniel Seidel and co-workers at Rutgers have reported in Organic Letters on an alpha-arylation/N-alkylation reaction.

N-alkylation

OL paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling | Leave a Comment »

Posted by naturalproductman on September 5, 2013

Masaya Sawamura and co-workers published in ACIE on a copper catalyzed three component coupling between an alkyl borane, tributyltin methoxide, and an alkynoate.

tin

ACIE paper

Posted in Copper, Methodology, Multi-Component Coupling, Transition Metal | Leave a Comment »

Benzyne intermediate

Posted by naturalproductman on August 30, 2013

Akkattu Biju and co-workers from CSIR have reported in Org Lett on a multi-component reaction involving a benzyne intermediate.

benzyne

OL paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling | Leave a Comment »

5 component cascade

Posted by naturalproductman on July 10, 2013

Jonathan George and co-workers from the University of Adeleide have reported in Org Lett on a five component cascade to synthesize penilactone A and B.

5

OL Paper

Posted in Methodology, Multi-Component Coupling, Total Synthesis | Leave a Comment »

Pd-catalyzed 3 component coupling

Posted by naturalproductman on March 13, 2013

Matthew Sigman and colleague at the University of Utah have reported in JACS on a palladium catalyzed three component coupling reaction.

three

JACS paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling, Palladium, Transition Metal | Leave a Comment »

Multi-component approach to guajadial B

Posted by naturalproductman on November 21, 2012

Looking at this molecule, one would never think that you can mix three things, a penta-substituted benzene ring, benzaldehyde and humulene, and obtain the final compound, guajadial! Ji-Kai Liu and co-workers at the Kunming Institute of Botany did such a thing!

MCC
OL paper

Posted in Biosynthesis, Cascade Reactions, Meroterpenoids, Methodology, Multi-Component Coupling, One pot, Total Synthesis | Leave a Comment »

Titanium mediated Ugi reaction

Posted by naturalproductman on September 7, 2012

Marco Ciufolini and co-workers have reported in Organic Letters on an Ugi reaction.

Ugi

OL paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling, Named Reactions, Titanium, Transition Metal, Ugi | Leave a Comment »

Three component coupling

Posted by naturalproductman on July 13, 2012

Masayuki Inoue and co-workers from University of Tokyo have reported in Organic Letters on a three component Pummerer reaction using V-40 [1,10-azobis(cyclohexane-1-carbonitrile)].
Pummerer

OL paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling, Named Reactions, Pummerer rearrangement | Leave a Comment »

CO incorporation with palladium

Posted by naturalproductman on April 19, 2012

Troels Skrydstrup and co-workers at the University of Aarhus in Denmark have reported in JOC on a palladium catalyzed multi-component coupling of a mono-substituted urea using carbon monoxide and an aryl halide.

Pd

JOC paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling, Palladium, Transition Metal | Leave a Comment »

2 dienes + 1 alkyne

Posted by naturalproductman on January 4, 2012

Phil Baran and co-workers have reported in JOC on a nickel catalyzed diene-alkyne cooligomerization reaction.

nickel

JOC paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling, Nickel, Transition Metal | Leave a Comment »

 
Follow

Get every new post delivered to your Inbox.

Join 66 other followers