Pd-catalyzed 3 component coupling

Matthew Sigman and colleague at the University of Utah have reported in JACS on a palladium catalyzed three component coupling reaction.

JACS paper

Multi-component approach to guajadial B

Looking at this molecule, one would never think that you can mix three things, a penta-substituted benzene ring, benzaldehyde and humulene, and obtain the final compound, guajadial! Ji-Kai Liu and co-workers at the Kunming Institute of Botany did such a thing!

OL paper

Titanium mediated Ugi reaction

Marco Ciufolini and co-workers have reported in Organic Letters on an Ugi reaction.

OL paper

Three component coupling

Masayuki Inoue and co-workers from University of Tokyo have reported in Organic Letters on a three component Pummerer reaction using V-40 [1,10-azobis(cyclohexane-1-carbonitrile)].

OL paper

CO incorporation with palladium

Troels Skrydstrup and co-workers at the University of Aarhus in Denmark have reported in JOC on a palladium catalyzed multi-component coupling of a mono-substituted urea using carbon monoxide and an aryl halide.

JOC paper

2 dienes + 1 alkyne

Phil Baran and co-workers have reported in JOC on a nickel catalyzed diene-alkyne cooligomerization reaction.

JOC paper

Vinyl bismuth via MCC

Akio Baba and co-workers at Osaka University have reported in ACIEE on a carbobismuthination reaction of an alkyne.

ACIEE paper

Double carbonylation

Laszlo Kollar and co-workers at the University of Pecs in Hungary have reported on a double carbonylation reaction that involved the incorporation of two CO groups onto a vinyl iodide – the fact that we see two carbon monoxide units introduced is probably related to the high pressure of CO (110 bar).  **(note:  typo in abstract “inluenced”)

Tetrahedron paper

Carbonylation of indoles with rhodium

Fuwei Li and co-workers from the Chinese Academy of Sciences have reported in Chemical Communications on a rhodium catalyzed three component carbonylative coupling.

Chem Comm paper

Olefin aminohydroxylation

Istvan Marko and co-workers at Université catholique de Louvain in Belgium have reported in Tetrahedron on a nice synthesis of Telaprevir using an oxaziridine and a lithium amide to functionalize an alkene.

Tetrahedron paper