Sialic acid synthesis

Xue-Wei Liu and co-workers from Nanyang Technological University in Singapore have reported in ACIEE on the synthesis of sialic acid starting from a dihydropyran.

ACIEE paper

N-chlorocarbamate = nitrene

Carl Lovely and colleague at UT Arlington have reported in Organic Letters on the use of an N-chlorocarbamate reagent that is basically the equivalent of a nitrene.  Interestingly they use an imidazolinium substrate – that we usually see in the benzoin condensations – and reacts with the N-chlorocarbamate reagent to form the new C-N double bond.

OL paper