Looking at this molecule, one would never think that you can mix three things, a penta-substituted benzene ring, benzaldehyde and humulene, and obtain the final compound, guajadial! Ji-Kai Liu and co-workers at the Kunming Institute of Botany did such a thing!
Archive for the ‘One pot’ Category
Posted by naturalproductman on November 21, 2012
Posted by naturalproductman on April 25, 2012
Zhigang Weng and co-workers from Shenzhen University have reported in Tetrahedron on a synthesis of angelone. The highlight is the cascade reaction forming the final product.
Posted by naturalproductman on October 19, 2011
Istvan Marko and co-workers at Université catholique de Louvain in Belgium have reported in Tetrahedron on a nice synthesis of Telaprevir using an oxaziridine and a lithium amide to functionalize an alkene.
Posted by naturalproductman on January 27, 2011
Jinxing Ye and co-workers at East China University of Science and Technology have published on a one pot organocatalytic reaction to form oxazines. I guess one pot reactions are all the craze now: