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Archive for the ‘Organocatalytic’ Category

Minovincine synthesis

Posted by naturalproductman on September 5, 2013

David Macmillan and co-workers have reported in ACIE on a synthesis of minovincine.

minovicine

ACIE paper

Posted in Alkaloids, Cascade Reactions, Methodology, Organocatalytic, Total Synthesis | Leave a Comment »

(−)-Aspidospermidine, (−)-Tabersonine, and (−)-Vincadifformine syntheses

Posted by naturalproductman on August 30, 2013

Rodrigo Andrade and colleague at Temple University have reported in JACS on a cascade synthesis of some aspidosperma alkaloids.

aspidosperma

JACS paper

Posted in Alkaloids, Cascade Reactions, Methodology, Organocatalytic, Total Synthesis | Leave a Comment »

KR by NHC

Posted by naturalproductman on July 24, 2013

Kenichi Yamada and co-workers at Kyoto University have reported in JACS on a kinetic resolution approach to resolve 1,2-diols.
NHC

JACS paper

Posted in Asymmetric, Kinetic resolution, Methodology, Organocatalytic | Leave a Comment »

Diyne desymmetrization

Posted by naturalproductman on May 21, 2013

Ulrich Hennecke and co-workers at the Universitat Munster have reported in JAC on a desymmetrization of a diyne.

Diyne

JACS paper

Posted in Alkaloids, Asymmetric, Cascade Reactions, Methodology, Organocatalytic | Leave a Comment »

Cinchona alkaloid catalyzed proton transfer

Posted by naturalproductman on May 14, 2013

Jin-Pei Cheng and co-workers from Nankai University have reported in JACS on a biomimetic proton transfer.

biomimetic

JACS paper

Posted in Asymmetric, Methodology, Organocatalytic | Leave a Comment »

[3,3]-Sigmatropic

Posted by naturalproductman on May 9, 2013

Laszlo Kurti and co-workers from UT Southwestern have reported in JACS on a [3,3]-sigmatropic rearrangement approach to access BINAM derivatives using a phosphoric acid catalyst.

organocatalyst

JACS paper

Posted in Asymmetric, Computational, DFT, Methodology, Organocatalytic | Leave a Comment »

Which point group is that organocatalyst?

Posted by naturalproductman on May 7, 2013

Hiromichi Fujioka and co-workers from Osaka University have reported in Organic Letters on a kinetic resolution of a  bromo-carboxylic acid using a C3-symmetric organocatalyst.

C3

OL paper

Posted in Asymmetric, Methodology, Organocatalytic | Leave a Comment »

N,N-Diphenylaminomethylene block

Posted by naturalproductman on May 7, 2013

Keiji Maruoka and co-workers have reported in JACS on an approach to form an alpha-quaternary chiral carbon center.

chiral

JACS paper

Posted in Asymmetric, Methodology, Organocatalytic | Leave a Comment »

Hydroamination via organocatalysis

Posted by naturalproductman on May 7, 2013

Eric Jacobsen and co-workers published in JACS on a hydroamination using a thiourea catalyst.  It’s refreshing to see a hydroamination without a transition metal.

hydroamination

JACS paper

Posted in Asymmetric, Methodology, Organocatalytic | Leave a Comment »

Asymmetric epoxidation

Posted by naturalproductman on April 19, 2013

Benjamin List and co-workers have reported in JACS on their studies of cinchona alkaloid catalyzed asymmetric epoxidation of activated olefins.

cinchona

JACS paper

Posted in Asymmetric, Computational, DFT, ESI, Mass Spectrometry, Mechanistic, Methodology, Organocatalytic | Leave a Comment »

 
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