Gold catalyzed [2+2]

Antonio Echavarren and co-workers from ICIQ in Spain have reported in Org Lett on a gold catalyzed intramolecular [2+2] between an alkene and alkyne.

OL paper

Towards maoecrystal V

John Chisholm and co-workers from Syracuse University have reported in Tetrahderon Letters on an intramolecular approach towards maeocrystal V.

TL paper

That’s pretty strained

Fumitoshi Kakiuchi and co-workers from Keio University have reported in Org Lett on a rhodium catalyzed [2+2] reaction between a terminal alkyne and an electron deficient alkene to form a cyclobutene.

OL paper

From furans to indoles

Peter Wipf and co-workers from University of Pittsburgh have reported in JOC on method for synthesis of 5-hydroxyindoles from furans.

JOC paper

Maeocrystal V synthesis

Danishefsky and colleague have reported in JACS on a racemic synthesis of maeocrystal V.

JACS paper

[2+2] by cationic gold

Jose Gonzalez and co-workers from the University of Oviedo have reported in ACIE on a cationic gold catalyzed [2+2] reaction.

ACIE paper

Jiadifenin synthesis

Hongbin Zhai and co-workers at SIOC have reported in ACIE on the synthesis of jiadifenin.  The key [2+2] installed the methyl ester substituent.

ACIE paper

Presilphiperfolan-1-ol synthesis

Stoltz and colleague have reported in ACIE on the enantioselective syntheses of some sesquiterpenoid biosynthetic precursors.  The 5,6-ring system was made from an intramolecular Diels-Alder.

ACIE paper

Acutimine approach

Sarah Reisman and colleague have reported in Organic Letters on their elegant approach to acutimine via a [2+2] cycloaddition – however, their retro-aldol reaction to open the cyclobutane ring failed.

OL paper

2 routes for elatenyne and is DFT going to be a standard for natural product structure assignment?

Deukjoon Kim (Seoul National University) and Jonathon Burton (University of Oxford) and co-workers have reported in JACS on a synthesis of elatenyne.

JACS paper