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Archive for the ‘Radical Chemistry’ Category

This reaction involves the formation of radicals to form new bonds.

Power of enzymes

Posted by naturalproductman on March 30, 2014

Kenji Watanabe and co-workers at Shizuoka University have reported in Chembiochem on the formation of dimeric diketopiperazine alkaloids from a cytochrome P450.

 

Chembiochem paper

Posted in Alkaloids, Cascade Reactions, Dimer, Methodology, Radical Chemistry | Leave a Comment »

Posted by naturalproductman on October 11, 2013

David Procter and co-workers have reported in JACS on an SmI2 promoted lactone opening.
radical

JACS paper

Posted in Methodology, Radical Chemistry | Leave a Comment »

Maoecrystal V synthesis

Posted by naturalproductman on September 25, 2013

Armen Zakarian and co-workers have reported in JACS on a synthesis of maoecrystal V.

maoecrystal V

JACS paper

Posted in C-H activation, Methodology, Radical Chemistry, Total Synthesis | Leave a Comment »

Radical C-C bond forming/breaking

Posted by naturalproductman on February 27, 2013

Samir Zard and colleague at CNRS have reported in JACS on a radical cascade C-C bond forming reaction.

radical

JACS paper

Posted in Cascade Reactions, Methodology, Radical Chemistry | Leave a Comment »

Installation of a nitro group

Posted by naturalproductman on February 26, 2013

Debabrata Maiti and co-workers from IIT Bombay have reported in JACS on a way to introduce nitro groups into olefins using TEMPO.

TEMPO

JACS paper

Posted in Methodology, Radical Chemistry, Silver, Transition Metal | Leave a Comment »

Lactone and allene radical cyclization

Posted by naturalproductman on July 20, 2012

David Procter and co-workers from the University of Manchester have reported in JACS on a SmI2-mediated radical cyclization of a lactone bearing an allene to form a 5,7-bicyclic ring system.

allene

JACS paper

Posted in Allenes, Methodology, Radical Chemistry, Seven-Membered Rings | Leave a Comment »

HAT

Posted by naturalproductman on July 3, 2012

Andreas Gansäuer and co-workers at Universitat Bonn have reported in ACIE on a HAT reaction to diastereoselectively and regioselectively open epoxides.

HAT
ACIE paper

Posted in Cascade Reactions, Methodology, Radical Chemistry, Titanium, Transition Metal | Leave a Comment »

Fusarisetin A synthesis

Posted by naturalproductman on June 21, 2012

Shuanhu Gao and co-workers at East China Normal University have reported in ACIE on the synthesis of fusarisetin through an intramolecular Diels-Alder in addition to an interesting manganese catalyzed radical cyclization to form an endoperoxide that is transformed to the tetrahydrofuran ring.

fusarisetin

ACIE paper

Posted in Alkaloids, Cascade Reactions, Manganese, Methodology, Radical Chemistry, Transition Metal | Leave a Comment »

Towards actinophyllic acid from radical cascade

Posted by naturalproductman on February 29, 2012

Tsuyoshi Taniguchi and co-workers at Kanazawa University have reported in Organic Letters on their progress towards actinophyllic acid via a radical cascade.

actinophyllic acid

OL paper

Posted in Alkaloids, Cascade Reactions, Methodology, Radical Chemistry | Leave a Comment »

Radical Fluorination

Posted by naturalproductman on February 23, 2012

Glenn Sammis and co-workers from the University of British Columbia have reported in JACS on a fluorination approach by generating a radical and using NFSI to fluorinate.

radical

JACS paper

Posted in Methodology, Radical Chemistry | Leave a Comment »

 
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