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Archive for the ‘Reactivity trends’ Category

Predicting the equilibrium of enamine formation

Posted by naturalproductman on January 7, 2012

Jaume Vilarassa and co-workers at Universitat de Barcelona in Spain have reported in Organic Letters on the tendency to form specific enamines in the presence of different carbonyl groups – for example aldehydes are more reactive in ketones generally except in the case where 1,3-dihydroxyacetone acetals are used as substrates to give rise to the enamine over alpha-branched aldehydes.
enamine

OL paper

Posted in Mechanistic, Methodology, Reactivity trends | Leave a Comment »

 
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