Naturalproductman’s Blog

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Archive for the ‘Ring forming’ Category

This reaction involves different ways to form rings from acyclic precursors.

Salvileucalin C synthesis

Posted by naturalproductman on June 6, 2014

Hanfeng Ding and co-workers from Zhejiang University have reported in Organic Letters on the synthesis of salvileucalin C. I thought of Sarah Reisman’s work but she of course made salvileucalin B. By the way, I noticed that Sarah Reisman was promoted directly from assistant prof to prof at Caltech so kudos to her.

salvileucalin C
OL paper

Posted in Methodology, Ring forming, Total Synthesis, Transannular | Leave a Comment »

Andrastin C synthesis

Posted by naturalproductman on November 19, 2012

Masahiro Toyota and co-workers from Tohoku University have reported in JOC on the synthesis of andrastin C.

andrastin C

JOC paper

Posted in Cascade Reactions, Methodology, Ring forming, Steroids | Leave a Comment »

Rhodium catalyzed reaction

Posted by naturalproductman on November 6, 2012

P. Andrew Evans (University of Liverpool) and Mu-Hyun Baik (Indiana University) and co-workers have published in JACS on a mechanistic investigation of a rhodium catalyzed [3+2+1] cyclization. The Los Alamos LACVP basis set was used to represent rhodium.

rhodium

JACS paper

Posted in Computational, DFT, Mechanistic, Methodology, Rhodium, Ring forming, Silver, Transition Metal | Leave a Comment »

FD-895 synthesis

Posted by naturalproductman on October 25, 2012

Michael Burkart and James J. La Clair and colleagues at UCSD have reported in Org Lett on the synthesis of

synthesis
OL paper

Posted in Macrolides, Metathesis, Methodology, Polyketides, Ring forming, Ruthenium, Structural Reassignment, Transition Metal | Leave a Comment »

Cyclization through fluorination

Posted by naturalproductman on October 25, 2012

Guosheng Liu and colleague at the Chinese Academy of Science have reported in Org Lett on a fluorination reaction that involves ring formation.
cyclization

OL paper

Posted in Cascade Reactions, Methodology, Ring forming | Leave a Comment »

3 rings from 1

Posted by naturalproductman on October 3, 2012

Jiong Yang and co-workers from Texas A&M have reported in JOC on a transannular Michael reaction.

transannular Michael

JOC paper

Posted in Cascade Reactions, Methodology, Michael, Named Reactions, Ring forming, Transannular | Leave a Comment »

Chain-walking reaction

Posted by naturalproductman on September 28, 2012

Takuya Kochi and co-workers at Keio University have reported in JACS on a chain walking reaction.

chain

JACS paper

Posted in Methodology, Palladium, Platinum, Ring forming, Transition Metal | Leave a Comment »

Benzyne cascade

Posted by naturalproductman on May 11, 2012

Richard Hsung and co-workers at the University of Wisconsin have reported in Organic Letters on a synthesis of chelidonine.

alkaloid

OL paper

Posted in Alkaloids, benzyne, Cascade Reactions, Methodology, Ring forming, Total Synthesis | Leave a Comment »

Bi-mediated [3+2]

Posted by naturalproductman on May 11, 2012

Elisabet Dunac and co-workers from CNRS have reported in Organic Letters on a Bi(OTf)3 mediated [3+2] between an allene and aryl group.

3+2

OL paper

Posted in Allenes, Methodology, Ring forming | Leave a Comment »

Mucosin synthesis

Posted by naturalproductman on February 23, 2012

Richard Whitby and co-workers from the University of Southampton have reported in Chemical Communications on the synthesis of mucosin via a zirconium catalyzed cyclization, which reminded me of the kind that Negishi had published before.

zirconium

Chemical Communications paper

Posted in Cascade Reactions, Methodology, Ring forming, Total Synthesis, Transition Metal, Zirconium | Leave a Comment »

 
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