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Archive for the ‘Spirocyclic centers’ Category

Gymnothelignan N synthesis

Posted by naturalproductman on August 18, 2014

Xuegong She and co-workers from Lanzhou University have reported in Organic Letters on the synthesis of

Friedel-Crafts

OL paper

Posted in Friedel-Crafts, Named Reactions, Spirocycles, Spirocyclic centers, Total Synthesis | Leave a Comment »

Polygalolide A synthesis

Posted by naturalproductman on November 17, 2011

Masaatsu Adachi and co-workers from Nagoya have reported in Organic Lettes on the synthesis of polygalolide A.

polygalolide A

OL paper

Posted in Asymmetric, Cascade Reactions, Methodology, Spirocyclic centers | Leave a Comment »

Ring rearrangement metathesis

Posted by naturalproductman on August 29, 2011

Nicolas Blanchard and co-workers at Universite de Haute-Alsace in France have reported in Chem Comm on  a spiroketalization via a ring rearrangement metathesis – add that to your new lexicon.

metathesis

Chem Comm paper

Posted in Cascade Reactions, Metathesis, Methodology, Ring forming, Ring Opening, Ruthenium, Spirocyclic centers, Spiroketals, Transition Metal | Leave a Comment »

4 component coupling for spiroindolines

Posted by naturalproductman on June 19, 2011

Laurent El Kaim and co-workers from CNRS have reported in Chem Comm on a multicomponent coupling approach to access spiroindolines.

spiroindolines

Chem Comm paper

Posted in Alkaloids, Copper, Methodology, Multi-Component Coupling, Radical Chemistry, Spirocyclic centers, Transition Metal | Leave a Comment »

Four component coupling for spirocycle

Posted by naturalproductman on April 11, 2011

Subbu Perumal and co-workers at Madurai Kamaraj University have reported in Tetrahedron on a four component coupling reaction in water.

four

Tetrahedron paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling, Spirocyclic centers | Leave a Comment »

Furans to Spiroketals via Singlet Oxygen

Posted by naturalproductman on February 25, 2011

Georgios Vassilikogiannakis and co-workers from the University of Crete report on the light induced spirocyclization reaction of a furan.

spiroketal

OBC paper

Posted in Cascade Reactions, Light Mediated, Methodology, Spirocycles, Spirocyclic centers, Spiroketals | Leave a Comment »

Isoquinocycline A Partial Synthesis

Posted by naturalproductman on February 21, 2011

Ulrich Koert and co-workers at Philipps-University Marburg have reported on the synthesis of the CDEFG ring system of isoquinoycline A.  An imidato alkenyl lithium was used as opposed to a dilithium reagent from the lactam form.

alkenyl lithium

 

OL paper

Posted in Cascade Reactions, Methodology, Spirocyclic centers | Leave a Comment »

Phenoxonium Ions

Posted by naturalproductman on December 31, 2010

Thomas Pettus and co-worker at UCSB have published in JACS on a lead(IV) acetate mediated (5+2) oxidative dearomatization to access some cedranoid sesquiterpenes.

oxidative

 

JACS paper

Posted in Cascade Reactions, Methodology, Ring forming, Sesquiterpenes, Spirocyclic centers | Leave a Comment »

Stemonamide Synthesis

Posted by naturalproductman on December 7, 2010

Fu-Min Zhang and co-workers at Lanzhou University have published in Chem Comm on a synthesis of stemonamide where a Schmidt reaction was used to access the 5,7-A,B-ring system.

stemonamide

Chem Comm paper

Posted in Aldol, Alkaloids, Dieckmann condensation, Methodology, Named Reactions, Schmidt, Spirocyclic centers, Titanium, Transition Metal | Leave a Comment »

Spirocyclization of an Allylic Carbonate

Posted by naturalproductman on October 11, 2010

Yasumasa Hamada and co-workers from Chiba University have published in Organic Letters on a palladium catalyzed spirocyclization of a phenol tethered by a allylic carbonate.

spirocyclization

 

OL paper

Posted in Friedel-Crafts, Methodology, Named Reactions, Palladium, Ring forming, Spirocyclic centers, Transition Metal, Tsuji-Trost | Leave a Comment »

 
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