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Archive for the ‘Transition Metal’ Category

Reactions involving transition metals

Silacarboxylation of allenes

Posted by naturalproductman on December 6, 2014

Yasushi Tsuji and co-workers have reported in JACS on a copper catalyzed silacarboxylation of allenes using carbon dioxide and a silylborane.

JACS paper

Posted in Allenes, Copper, Methodology, Transition Metal | Leave a Comment »

Dibromoalkenes from alkynes

Posted by naturalproductman on November 29, 2014

Weimin He and co-workers from Hunan University have reported in JOC on the synthesis of E-dibromoalkenes from alkynes using CuBr2.
copper

JOC paper

Posted in Cascade Reactions, Copper, Methodology, Transition Metal | Leave a Comment »

Multi-component coupling with cobalt

Posted by naturalproductman on November 28, 2014

Xiaobing Wan and co-workers from Soochow University have reported in ACIE on a multi-component coupling approach to access β-Ester-γ-amino ketones.

tbhp

ACIE paper

Posted in Cascade Reactions, Cobalt, Methodology, Multi-Component Coupling, Transition Metal | Leave a Comment »

N-Tosyl hydrazones to alkynes with copper

Posted by naturalproductman on November 28, 2014

Huanfeng Jiang and co-workers from South China University of Technology have reported in ACIE on a copper catalyzed conversion of N-tosyl hydrazones to alkynes. The problem is I don’t know how regioselective this is.

copper

ACIE paper

Posted in Copper, Methodology, Transition Metal | 1 Comment »

Exo vs. endo

Posted by naturalproductman on November 8, 2014

Nicolai Cramer and colleague at EPFL in Switzerland have reported in ACIE on a Ni catalyzed cyclization that undergoes endo or exo cyclization depending on the use of either a carbene or a cyclooctadiene ligand.

cyclo octadiene

ACIE paper

Posted in Methodology, Nickel, Transition Metal | Leave a Comment »

Ascospiroketal A synthesis

Posted by naturalproductman on November 8, 2014

Robert Britton and co-workers from Simon Fraser University have reported in ACIE on the synthesis of ascospiroketal A through a silver cascade reaction.

silver

ACIE paper

Posted in Cascade Reactions, Methodology, Silver, Total Synthesis, Transition Metal | Leave a Comment »

Neopeltolide through metathesis

Posted by naturalproductman on November 8, 2014

Hoveyda and co-workers have reported in ACIE on the synthesis of neopeltolide.

metathesis

ACIE paper

Posted in Metathesis, Methodology, Ruthenium, Total Synthesis, Transition Metal | Leave a Comment »

Alkyl halides from aryl halides

Posted by naturalproductman on November 8, 2014

Zhenfeng Xi and co-workers from SIOC have reported in ACIE on the transfer of a halogen from an aryl group to an alkyl group.

reductive elimination

ACIE paper

Posted in Mechanistic, Methodology, Palladium, Transition Metal | Leave a Comment »

Pd pi-allyl

Posted by naturalproductman on November 8, 2014

Shu-Li You and co-workers at SIOC have reported in JACS on some mechanistic studies of a Pd pi-allyl chemistry.

pi allyl

JACS paper

Posted in Asymmetric, Mechanistic, Methodology, Named Reactions, Palladium, Transition Metal, Tsuji-Trost | Leave a Comment »

Disorazole through cross metathesis

Posted by naturalproductman on November 8, 2014

Hoveyda and co-workers from Boston College have reported in JACS on a Z-selective cross coupling to access this C2-symmetric molecule – using alkenyl boronate and alkenyl iodide moieties.
metathesis

JACS paper

Posted in Alkaloids, C2-Symmetric, Metathesis, Methodology, Oxazoles, Ruthenium, Transition Metal | Leave a Comment »

 
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