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Archive for the ‘Manganese’ Category

Spirangien A synthesis

Posted by naturalproductman on January 17, 2013

Mark Rizzacasa and co-workers from the University of Melbourne have reported in Organic Letters on their formal synthesis of spirangien A.

spirangien A

OL paper

Posted in Iron, Manganese, Metathesis, Methodology, Polyketides, Spiroketals, Transition Metal | Leave a Comment »

Manganese catalyzed fluorination

Posted by naturalproductman on September 17, 2012

John Groves and co-workers have reported in Science on a manganese promoted fluorination process of aliphatics.

 

Science paper

Posted in C-H activation, Manganese, Methodology, Transition Metal | Leave a Comment »

Selective C-H activation process

Posted by naturalproductman on August 21, 2012

Konstantin Bryliakov and co-workers at the Boreskov Institute of Catalysis in Russia have reported in Organic Letters on a selective C-H activation process.

C-H

OL paper

Posted in C-H activation, Manganese, Methodology, Transition Metal | Leave a Comment »

Fusarisetin A synthesis

Posted by naturalproductman on June 21, 2012

Shuanhu Gao and co-workers at East China Normal University have reported in ACIE on the synthesis of fusarisetin through an intramolecular Diels-Alder in addition to an interesting manganese catalyzed radical cyclization to form an endoperoxide that is transformed to the tetrahydrofuran ring.

fusarisetin

ACIE paper

Posted in Alkaloids, Cascade Reactions, Manganese, Methodology, Radical Chemistry, Transition Metal | Leave a Comment »

Chloroacetonylation

Posted by naturalproductman on December 21, 2011

Metin Balci and co-workers at Middle East Technical University in Turkey have reported in Tetrahedron Letters on a manganese acetate promoted chloroacetonylation across an olefin.

manganese
TL paper

Posted in Cascade Reactions, Manganese, Methodology, Transition Metal | Leave a Comment »

Dimanganese hydroxylase

Posted by naturalproductman on September 19, 2011

Yi Tang and co-workers from UCLA have reported in JACS on the characterization of a hydroxylase enzyme made up of two manganese metal centers responsible for catalysis.

dimanganese
JACS paper

Posted in Anthracenes, Chemical Biology, Manganese, Polyketides, Transition Metal | Leave a Comment »

Ageliferin synthesis

Posted by naturalproductman on September 9, 2011

Chuo Chen and colleagues at UT Southwestern have reported in JACS on their synthesis of ageliferin, featuring a Mn-promoted cascade radical cyclization.

Mn

JACS paper

Posted in Alkaloids, Asymmetric, Cascade Reactions, Manganese, Methodology, Radical Chemistry, Transition Metal | Leave a Comment »

Manganese C-H Activation

Posted by naturalproductman on March 4, 2011

Douglas Taber and colleague have reported in JOC on a manganese catalyzed C-H activation process to form one of the rings in (−)-cameroonan-7α-ol.

C-H


JOC paper

Posted in C-H activation, Cascade Reactions, Manganese, Methodology, Radical Chemistry, Rhodium, Ring forming, Transition Metal | Leave a Comment »

Mn-Catalyzed Chlorination

Posted by naturalproductman on August 31, 2010

John Groves and co-worker at Princeton have published in JACS on a manganese porphyrin mediated C-H chlorination reaction using sodium hypochlorite as the chlorine source.  The yields and regioselectivity are modest for the more complex systems but it’s cool nonetheless.

sodium hypochlorite

JACS paper

Posted in C-H activation, Manganese, Methodology, Transition Metal | Leave a Comment »

Synthesis of Ialibinones

Posted by naturalproductman on August 13, 2010

Nigel Simpkins and co-worker at the University of Birmingham have published in Tetrahedron Letters on a manganese/copper mediated oxidative cyclization reaction to access ialibinone.

ialibinones A and B

TL paper

Posted in Cascade Reactions, Copper, Manganese, Methodology, Total Synthesis, Transition Metal | Leave a Comment »

 
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