Naturalproductman’s Blog

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Archive for the ‘Molybdenum’ Category

Artemisinin synthesis

Posted by naturalproductman on August 6, 2012

Silas Cook and colleague at Indiana University have reported in JACS on a synthesis of artemisinin using a molybdenum promoted in situ formation of singlet oxygen to form the endoperoxide.

hydrogen peroxide

JACS paper

Posted in Cascade Reactions, Diseases, Malaria, Methodology, Molybdenum, Total Synthesis, Transition Metal | Leave a Comment »

E alkene from E/Z-mixture

Posted by naturalproductman on July 7, 2011

Ever want to selectively isolate the E-isomer of a E/Z-mixture of alkenes?  Well Hoveyda and Schrock have reported in JACS on the use of a molybdenum catalyst (monoaryloxide-pyrrolide – ie:  MAP – complex with molybdenum) in the presence of ethylene to completely abolish the Z-alkene from the mixture via ethenolysis.

molybdenum

JACS paper

Posted in Carbene, Cascade Reactions, Kinetic resolution, Metathesis, Methodology, Molybdenum, Transition Metal | Leave a Comment »

Z-selective Olefin Metathesis

Posted by naturalproductman on March 24, 2011

Hoveyda and co-workers at Boston College have reported in Nature on a Z-selective olefin metathesis reaction.

 

Nature paper

Posted in Carbene, Metathesis, Methodology, Molybdenum, Transition Metal | Leave a Comment »

Isolysergol Synthesis

Posted by naturalproductman on May 12, 2010

Stephen Martin and co-worker at UT Austin have published in Organic Letters on an asymmetric synthesis of isolysergol via an enantioselective ring closing metathesis reaction to afford the dihydropiperidine ring.  They used a chiral molybdenum catalyst for the ring closing metathesis reaction.

arcm
OL paper

Posted in Alkaloids, Asymmetric, Metathesis, Methodology, Molybdenum, Transition Metal | Leave a Comment »

 
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