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Archive for the ‘Titanium’ Category

C-C bond cleavage with titanium

Posted by naturalproductman on August 28, 2014

Zhaomin Hou and co-workers at RIKEN (Saitama, JP) have reported in Nature on a titanium hydride complex that cleaves carbon-carbon bonds.

 

Nature paper

Posted in C-C Bond Breaking, Methodology, Titanium, Transition Metal | Leave a Comment »

Polyene cyclization with titanocene

Posted by naturalproductman on May 6, 2014

Juan Cuerva and co-workers from the University of Granada in Spain have reported in JACS on a titanocene mediated polyolefin cyclization reaction that studied with Gaussian calculations. The basis set used to approximate the titanocene catalyst was 6-31G*. From my little knowledge of Gaussian, when using QM calculations to study a reaction mechanism, you need two things: 1) the basis set and 2) the method. The basis set is the linear combination of a set of functions used to approximate the molecular orbitals. There are many kinds of basis sets that can be used for Gaussian. In my experience with transition metals however, I was unable to use the 6-31G* basis set because the transition metals have more complicated molecular orbitals since they have d-orbitals. I had to use the Los Alamos basis set: LANL2Dz. I eventually gave up on my time with Gaussian because I just kept running into problems and eventually had to focus my efforts into experimental work. But hopefully one day I can go back to this stuff again. Afterall, it helps us understand the reaction mechanisms better.

titanocene

JACS paper

Posted in Cascade Reactions, Computational, DFT, Methodology, Titanium, Transition Metal | Leave a Comment »

ATR-FTIR-UV/Vis monitoring of a reaction

Posted by naturalproductman on March 13, 2013

Ursula Bentrup and co-workers at Universitat Rostock in Germany have reported in Tetrahedron on an interesting setup to monitor a reaction.

monitor

Tetrahedron paper

Posted in Mechanistic, Methodology, New Setups, Titanium, Transition Metal | Leave a Comment »

Titanium mediated Ugi reaction

Posted by naturalproductman on September 7, 2012

Marco Ciufolini and co-workers have reported in Organic Letters on an Ugi reaction.

Ugi

OL paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling, Named Reactions, Titanium, Transition Metal, Ugi | Leave a Comment »

HAT

Posted by naturalproductman on July 3, 2012

Andreas Gansäuer and co-workers at Universitat Bonn have reported in ACIE on a HAT reaction to diastereoselectively and regioselectively open epoxides.

HAT
ACIE paper

Posted in Cascade Reactions, Methodology, Radical Chemistry, Titanium, Transition Metal | Leave a Comment »

Cationic cascade

Posted by naturalproductman on July 2, 2012

Teck Peng Loh and co-workers from the University of Science and Technology in China have reported in ACIE on a cationic cascade to access 8-oxotropanes.

cationic

ACIE paper

Posted in Cascade Reactions, Methodology, Seven-Membered Rings, Titanium, Transition Metal | Leave a Comment »

Friedel-Crafts cascade

Posted by naturalproductman on April 4, 2012

Arun Ghosh and co-workers from Purdue have reported in Organic Letters on a Friedel-Crafts cascade to form a seven membered ring.
seven

OL paper

Posted in Carbene, Cascade Reactions, Friedel-Crafts, Methodology, Named Reactions, Seven-Membered Rings, Titanium, Transition Metal | Leave a Comment »

Cyclobutane via radical cascade

Posted by naturalproductman on January 25, 2012

Andreas Gansauer and co-workers at the Universitat Bonn have reported in Chemistry a European Journal on an interesting mechanistic investigation of a cyclobutane forming reaction using a titanium catalyst.

radical

Chemistry – a European Journal paper

Posted in Cascade Reactions, Computational, DFT, Mechanistic, Methodology, Radical Chemistry, Ring forming, Titanium, Transition Metal | Leave a Comment »

Maoecrystal Z synthesis

Posted by naturalproductman on August 30, 2011

Sarah Reisman and co-workers have reported in JACS on a total synthesis of maoecrystal Z featuring a samarium mediated radical redutive cyclization of a dialdehyde intermediate.

maoecrystal Z

JACS paper

 

Isolation paper in OL

Posted in breast, Cancer, Cascade Reactions, Diterpene, leukemia, Methodology, ovarian, Radical Chemistry, Titanium, Transition Metal | Leave a Comment »

Titanium mediated radical cascade

Posted by naturalproductman on March 5, 2011

Chakraborty and co-workers at CSIR have reported in Tetrahedron Letters on a titanium radical mediated epoxide rearrangement to form cyclopentanes.

titanium

TL paper

Posted in Cascade Reactions, Methodology, Titanium, Transition Metal | Leave a Comment »

 
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