Anthony Barrett and co-workers at Imperial College have reported in Organic Letters on a cascade reaction that involves the formation of a ketene followed by trapping with an enamine to form pyridinones.
Carreira and co-workers have reported in ACIEE on an autocatalysis reaction. Normally we think of an asymmetric reaction involving the substrate, reagent, and a catalyst with a chiral ligand. In this case, they are adding a fourth realm: the product itself and in enantiomerically pure form. They are saying that the addition of the product which is in high ee would increase the overall enantioselectivity of this reaction. I have some questions about this like: wouldn’t the composition of the enantiomerically pure product you’re adding to the reaction contribute to the ee of the final reaction?