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Archive for the ‘Zirconium’ Category

Mucosin synthesis

Posted by naturalproductman on February 23, 2012

Richard Whitby and co-workers from the University of Southampton have reported in Chemical Communications on the synthesis of mucosin via a zirconium catalyzed cyclization, which reminded me of the kind that Negishi had published before.

zirconium

Chemical Communications paper

Posted in Cascade Reactions, Methodology, Ring forming, Total Synthesis, Transition Metal, Zirconium | Leave a Comment »

Enantiospecific Suzuki-Miyaura

Posted by naturalproductman on December 5, 2011

Michinori Suginome and co-workers at Kyoto University have published in JACS on the enantiospecificity of a Suzuki-Miyaura reaction and they show that inversion or retention can occur depending on the additive.

Suzuki-Miyaura

JACS paper

Posted in Asymmetric, cross coupling, Methodology, Palladium, Suzuki-Miyaura, Transition Metal, Zirconium | Leave a Comment »

Introducing a trifluoro group

Posted by naturalproductman on August 26, 2011

Erick Carreira and co-worker have reported in ACIEE on a way to introduce a trifluoroethyl group onto either a cyclic ketone or aldehyde using a Zr-catalyst.

trifluoro

ACIEE paper

Posted in C-C Bond Breaking, Cascade Reactions, Methodology, Transition Metal, Zirconium | Leave a Comment »

1,6-Conjugate Addition with Copper

Posted by naturalproductman on September 1, 2010

Marc Mauduit and co-workers have published in Organic Letters on a 1,6-conjugate addition of an organozinc reagent using a catalytic amount of copper (II) triflate.

1,6-addition

OL paper

Posted in Conjugate Additions, Copper, Methodology, Transition Metal, Zirconium | Leave a Comment »

Cumulenes from Diynes

Posted by naturalproductman on June 24, 2010

Yuxue Li and co-workers from the Chinese Academy of Sciences have published in Organometallics on the use of benzynezirconocenes and diynes to form cumulenes.

cumulene

Organometallics paper

Posted in Cascade Reactions, Methodology, Transition Metal, Zirconium | Leave a Comment »

 
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