Naturalproductman’s Blog

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Archive for the ‘X-H insertion’ Category

O-H Insertion

Posted by naturalproductman on December 8, 2009

Huw Davies and co-worker at Emory have recently reported in JACS on the use of an alpha,alpha-diazo-benzyl methyl ester to a chiral tertiary alcohol using a secondary alcohol and a asymmetric rhodium dimer catalyst.  The reaction involves an O-H insertion step followed by a [2,3]-sigmatropic rearrangement.  This chemistry reminds us how Michael Doyle’s methodology is very important in the field.

cascade

JACS paper

Posted in Asymmetric, Cascade Reactions, Methodology, Transition Metal, X-H insertion | Leave a Comment »

 
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