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Archive for the ‘Named Reactions’ Category

4-Hydroxycyclopentenones from furans

Posted by naturalproductman on November 16, 2014

Javier Read de Alaniz and co-workers from UCSB have reported in Tetrahedron Letters on the synthesis of cyclopentenones from furans through a Piancatelli rearrangement.
Piancatelli
TL paper

Posted in Cascade Reactions, Methodology, Named Reactions, Piancatelli rearrangement, Ring Opening | 1 Comment »

Pd pi-allyl

Posted by naturalproductman on November 8, 2014

Shu-Li You and co-workers at SIOC have reported in JACS on some mechanistic studies of a Pd pi-allyl chemistry.

pi allyl

JACS paper

Posted in Asymmetric, Mechanistic, Methodology, Named Reactions, Palladium, Transition Metal, Tsuji-Trost | Leave a Comment »

Asymmetric aza-Pinacol rearrangement

Posted by naturalproductman on November 4, 2014

Yong-Gui Zhou and co-workers at SIOC have reported in JACS on an asymmetric aza-Pinacol rearrangement.

asymmetric

JACS paper

Posted in Asymmetric, Aza-Pinacol, Cascade Reactions, Methodology, Named Reactions, Palladium, Ring expansion, Transition Metal | Leave a Comment »

Synthesis of 6-Deoxypladienolide D, which binds to SF3B1

Posted by naturalproductman on October 28, 2014

Gregg Keaney and co-workers at H3 Biomedicine have reported in Org Lett on the synthesis of 6-deoxypladienolide D.
6-deoxypladienolide D

OL paper

Posted in Named Reactions, Polyketides, Suzuki-Miyaura, Total Synthesis | 1 Comment »

Paracaseolide A synthesis

Posted by naturalproductman on October 25, 2014

Goverdhan Mehta (University of Hyderabad) and co-workers at IIT Hyderabad have reported in Tetrahedron on the synthesis of paracaseolide A.
paracaseolide A

Tetrahedron paper

Posted in Diels-Alder, Named Reactions, Total Synthesis | Leave a Comment »

Strained alkynes are in

Posted by naturalproductman on October 25, 2014

Rick Danheiser and colleague have reported in JACS on the synthesis of an aza-cyclohexyne to do the chemistries that other people have been doing with benzynes.

alkyne

JACS paper

Posted in Diels-Alder, Methodology, Named Reactions, [2+2] | Leave a Comment »

Interrupted Nazarov

Posted by naturalproductman on October 7, 2014

FG West and co-workers from the University of Alberta have reported in an Nazarov cyclization study combining DFT and experiment to explain the diastereoselectivity.

 

 

JACS paper

Posted in Cascade Reactions, Methodology, Named Reactions, Nazarov cyclization | Leave a Comment »

Hyperuralones A and B

Posted by naturalproductman on September 8, 2014

Gang Xu and co-workers from the Chinese Academy of Sciences have reported in Organic Letters on the isolation of hyperuralones A and B, which had low micro molar IC50 activity against cancer cells.

cancer

OL paper

Posted in Cancer, Diels-Alder, Isoprenoids, Named Reactions | Leave a Comment »

Oxepanes via Ferrier

Posted by naturalproductman on August 31, 2014

Srinivasan Chandrasekaran and co-workers at the Indian Institute of Science have reported in Tetrahedron on a Ferrier rearrangement to form oxepanes.

 

Ferrier

Tetrahedron paper

Posted in Cascade Reactions, Ferrier, Methodology, Named Reactions, Ring expansion, Ring Opening | Leave a Comment »

Breaking benzene

Posted by naturalproductman on August 28, 2014

Petr Beier and co-workers from the Academy of the Sciences of the Czech Republic have reported in JOC on an interesting reaction involving hydrogen peroxide, and an SF5-phenol to afford a muconolactone derivative.

BV
JOC paper

Posted in Cascade Reactions, Mechanistic, Methodology, Named Reactions | Leave a Comment »

 
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