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Archive for the ‘Named Reactions’ Category

Interrupted Nazarov

Posted by naturalproductman on October 7, 2014

FG West and co-workers from the University of Alberta have reported in an Nazarov cyclization study combining DFT and experiment to explain the diastereoselectivity.

 

 

JACS paper

Posted in Cascade Reactions, Methodology, Named Reactions, Nazarov cyclization | Leave a Comment »

Hyperuralones A and B

Posted by naturalproductman on September 8, 2014

Gang Xu and co-workers from the Chinese Academy of Sciences have reported in Organic Letters on the isolation of hyperuralones A and B, which had low micro molar IC50 activity against cancer cells.

cancer

OL paper

Posted in Cancer, Diels-Alder, Isoprenoids, Named Reactions | Leave a Comment »

Oxepanes via Ferrier

Posted by naturalproductman on August 31, 2014

Srinivasan Chandrasekaran and co-workers at the Indian Institute of Science have reported in Tetrahedron on a Ferrier rearrangement to form oxepanes.

 

Ferrier

Tetrahedron paper

Posted in Cascade Reactions, Ferrier, Methodology, Named Reactions, Ring expansion, Ring Opening | Leave a Comment »

Breaking benzene

Posted by naturalproductman on August 28, 2014

Petr Beier and co-workers from the Academy of the Sciences of the Czech Republic have reported in JOC on an interesting reaction involving hydrogen peroxide, and an SF5-phenol to afford a muconolactone derivative.

BV
JOC paper

Posted in Cascade Reactions, Mechanistic, Methodology, Named Reactions | Leave a Comment »

Stereospecific Aggarwal boronate rearrangement

Posted by naturalproductman on August 28, 2014

Chris Senanayake and co-workers from Boehringer Ingelheim have reported in Organic Letters on an interesting transformation involving a lithiated carbamate and a boronate.

boron

OL paper

Posted in Cascade Reactions, Methodology, Named Reactions | Leave a Comment »

Gymnothelignan N synthesis

Posted by naturalproductman on August 18, 2014

Xuegong She and co-workers from Lanzhou University have reported in Organic Letters on the synthesis of

Friedel-Crafts

OL paper

Posted in Friedel-Crafts, Named Reactions, Spirocycles, Spirocyclic centers, Total Synthesis | Leave a Comment »

Delta12-prostaglandin J3 synthesis

Posted by naturalproductman on August 18, 2014

Nicolaou and co-workers have reported in ACIE on the synthesis of delta12-prostaglandin J3.

prostaglandin J3

ACIE paper

Posted in Aldol, Cancer, leukemia, Methodology, Polyenes, Prostaglandins, Total Synthesis | Leave a Comment »

Cavicularin synthesis

Posted by naturalproductman on August 18, 2014

Christopher Beaudry and colleague at Oregon State have reported in ACIE on the synthesis of cavicularin through a Diels-Alder with a vinyl sulfone dienophile.

Diels Alder

ACIE paper

Posted in Aromatic, Diels-Alder, Methodology, Total Synthesis | Leave a Comment »

Mannopeptimycin aglycone synthesis

Posted by naturalproductman on August 18, 2014

Takayuki Doi and co-workers at Tohoku University have reported in JACS on the synthesis of mannopeptimycin aglycone.

mannopeptimycin aglycone

JACS paper

Posted in Aldol, Methodology, Peptides | Leave a Comment »

Rhodium cascade

Posted by naturalproductman on July 16, 2014

Richmond Sarpong and co-workers have reported in ACIE on a rhodium catalyzed cascade reaction involving an aza-Cope rearrangement.

Cope

ACIE paper

Posted in Aza-Cope rearrangement, Cascade Reactions, Methodology, Named Reactions, Rhodium, Transition Metal | Leave a Comment »

 
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