Mycosporulone synthesis

Michael Jung and colleague at UCLA have reported in Organic Letters on the synthesis of mycosporulone.

OL paper

GB-13 synthesis

David Evans and co-workers have reported in JACS on their synthesis of GB-13.

JACS paper

Hirsutellone B synthesis

Hiromi Uchiro and co-workers from Tokyo University of Science have reported in Organic Letters on the total synthesis of hirsutellone.

OL paper

Alpha-chloro group slows enamine formation

Keiji Maruoka and co-workers at Kyoto University have reported in JACS on a cross-Aldol coupling between two distinct aldehydes, one with an alpha-chloro group.  It turns out that the chloride group slows down the enamine formation.

JACS paper

Isatisine A synthesis

Guanxin Liang and co-workers from Nankai University have reported  in ACIEE on their total synthesis of isatisine.

ACIEE paper

Rippertenol synthesis

Scott Snyder and co-workers have reported in JACS on their synthesis of rippertenol.

JACS paper

Lactones make enolate surrogates

Akira Yanagisawa and co-workers at Chiba University have reported in Organic Letters on the use of β,γ-didehydro-γ-lactone as tin-enolate precursors to effect an Aldol reaction.

 

OL paper

Stemonamide Synthesis

Fu-Min Zhang and co-workers at Lanzhou University have published in Chem Comm on a synthesis of stemonamide where a Schmidt reaction was used to access the 5,7-A,B-ring system.

Chem Comm paper

Cortistatin Access

Hongbing Zhai and co-workers at the Shanghai Institute of Organic Chemistry have published in Organic Letters on their progress towards cortistatin, which involves a double Aldol reaction of a ketone-dialdehyde to access the 6,7,6-tricyclic ring structure.

OL paper

Heptemerone G Synthesis

Jerzy Wicha and co-workers at the Polish Academy of Sciences have published in Tetrahedron Letters on the synthesis of heptemerone G.  They started from the 5,7-bicyclic portion and formed the 6 membered ring via an Aldol condensation.

TL paper