The Meerwein-Ponndorf-Verley reduction is the opposite of the Oppenauer oxidation. Kei Takeda and co-workers from Hiroshima University have reported in ACIEE on a Meerwein-Ponndorf-Verley type reduction of an acyl silane followed by a Brooke rearrangement to afford siloxyallenes. They were able to trap these allenes with a dienophile to undergo a [4+2] cycloaddition.
Archive for the ‘Brooke rearrangement’ Category
Posted by naturalproductman on June 2, 2011
Posted by naturalproductman on May 12, 2010
Kei Takeda and co-workers at Hiroshima University have recently published in JOC on a diastereoselective Brooke rearrangement for the synthesis of prelaureatin.