Naturalproductman’s Blog

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Archive for the ‘Curtius rearrangement’ Category

NP25302 synthesis

Posted by naturalproductman on October 19, 2011

Jeremy Robertson and co-workers at the University of Oxford have reported in Organic Letters on the synthesis of NP25302 taking advantage of a TMSOTf mediated 5-endo-dig cyclization followed by a Curtius rearrangement to form the Csp2-nitrogen bond.

NP25302

OL paper

Posted in Alkaloids, Cancer, Cascade Reactions, Curtius rearrangement, leukemia, Methodology, Named Reactions | Leave a Comment »

Pancrastatin synthesis

Posted by naturalproductman on October 11, 2011

Cheon-Gyu Cho at Hanyang University in Korea have reported in Organic Letters on their synthesis of pancrastatin.

pancrastatin

OL paper

Posted in Alkaloids, Bischler-Napieralski reaction, Cascade Reactions, Curtius rearrangement, Cycloaddition, Diels-Alder, Methodology, Named Reactions, Pericyclic reactions | Leave a Comment »

 
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