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Archive for the ‘Diels-Alder’ Category

Mogolides A and B syntheses

Posted by naturalproductman on November 28, 2014

Yefeng Tang and co-workers from Tsinghua University have reported in ACIE on the synthesis mogolides A and B.

biomimetic

ACIE paper

Posted in Diels-Alder, Dimer, Named Reactions, Polyketides, Total Synthesis | Leave a Comment »

Paracaseolide A synthesis

Posted by naturalproductman on October 25, 2014

Goverdhan Mehta (University of Hyderabad) and co-workers at IIT Hyderabad have reported in Tetrahedron on the synthesis of paracaseolide A.
paracaseolide A

Tetrahedron paper

Posted in Diels-Alder, Named Reactions, Total Synthesis | Leave a Comment »

Strained alkynes are in

Posted by naturalproductman on October 25, 2014

Rick Danheiser and colleague have reported in JACS on the synthesis of an aza-cyclohexyne to do the chemistries that other people have been doing with benzynes.

alkyne

JACS paper

Posted in Diels-Alder, Methodology, Named Reactions, [2+2] | Leave a Comment »

Hyperuralones A and B

Posted by naturalproductman on September 8, 2014

Gang Xu and co-workers from the Chinese Academy of Sciences have reported in Organic Letters on the isolation of hyperuralones A and B, which had low micro molar IC50 activity against cancer cells.

cancer

OL paper

Posted in Cancer, Diels-Alder, Isoprenoids, Named Reactions | Leave a Comment »

Cavicularin synthesis

Posted by naturalproductman on August 18, 2014

Christopher Beaudry and colleague at Oregon State have reported in ACIE on the synthesis of cavicularin through a Diels-Alder with a vinyl sulfone dienophile.

Diels Alder

ACIE paper

Posted in Aromatic, Diels-Alder, Methodology, Total Synthesis | Leave a Comment »

Claisen-Diels-Alder cascade to spirooliganones A and B

Posted by naturalproductman on July 16, 2014

Rongbiao Tong and co-workers from the Hong Kong University of Science and Technology have reported in Org Lett on a slick reaction to form spirooliganones.

 
spirooliganones

OL paper

Posted in Cascade Reactions, Claisen rearrangement, Diels-Alder, Methodology, Named Reactions, Total Synthesis | Leave a Comment »

Bolivianine synthesis

Posted by naturalproductman on June 11, 2013

Bo Liu and co-workers at Sichuan University have reported in JACS on a synthesis of bolivianine using a Diels-Alder cascade for the final key step.

JACS paper

Posted in Diels-Alder, Named Reactions, Total Synthesis | Leave a Comment »

Transtaganolide syntheses

Posted by naturalproductman on May 17, 2013

Brian Stoltz and co-workers have reported in ACIE on the syntheses of transtaganolides through an Ireland-Claisen rearrangement/Diels-Alder cascade.

ICR/DA

ACIE paper

Posted in Asymmetric, Cascade Reactions, Claisen rearrangement, Diels-Alder, Methodology, Named Reactions, Sesquiterpenes, Total Synthesis | Leave a Comment »

Towards PF-1018

Posted by naturalproductman on April 2, 2013

Dirk Trauner and co-workers at have reported in Organic Letters on a Stille-Diels Alder cascade approach towards PF-1018.

PF-1018

OL paper

Posted in Cascade Reactions, cross coupling, Diels-Alder, Methodology, Named Reactions, Stille | Leave a Comment »

Kingianin synthesis

Posted by naturalproductman on March 6, 2013

Michael Sherburn and co-workers from Australian National University have reported in ACIE on the synthesis of kingianins A, D, and F from a poly-yne precursor.  Ledwith-Weitz salt was used to promote a Diels-Alder dimerization.

Diels-Alder

 

ACIE paper

Posted in Cascade Reactions, Diels-Alder, Ledwith-Weitz salt, Methodology, Named Reactions, Total Synthesis | Leave a Comment »

 
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