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Archive for the ‘Grignard’ Category

Regioselective epoxide opening

Posted by naturalproductman on October 23, 2011

Pilar López-Ram-de-Víu and co-workers have reported in Organic and Biomolecular Chemistry on an epoxide opening reaction using a Grignard reagent – and the regioselectivity is switched when they use it in the presence of copper bromide.

epoxide

OBC paper

Posted in Copper, Grignard, Methodology, Named Reactions, Named Reagents, Regioselective, Ring Opening, Transition Metal | Leave a Comment »

Kumada Coupling with Retention

Posted by naturalproductman on May 13, 2011

Mark Biscoe and co-workers have published in JACS on a Kumada coupling between an aryl bromide or triflate and an sp3-Grignard involving a nickel catalyst and a carbene ligand.

Kumada

JACS paper

Posted in cross coupling, Grignard, Kumada, Methodology, Named Reactions, Nickel, Transition Metal | Leave a Comment »

Cascade with Grignard

Posted by naturalproductman on May 12, 2011

Ben Feringa and co-workers at have reported in ACIEE on a cascade reaction that involves the conjugate addition of a Grignard followed by an oxidative cyclization.

cyclization

ACIEE paper

Posted in Copper, Grignard, Methodology, Named Reactions, Radical Chemistry, Transition Metal | Leave a Comment »

New Tricks with Grignard

Posted by naturalproductman on December 17, 2010

Chenzhong Cao and co-workers at Hunan University of Science and Technology have published in Organic Letters on a Grignard addition onto isopropenyl acetate to form 1,3-diols.

Grignard

 

OL paper

Posted in Cascade Reactions, Grignard, Methodology, Named Reactions | Leave a Comment »

Grignard Approach for Olefination

Posted by naturalproductman on April 22, 2010

Songlin Zhang and co-workers from the Chemical Engineering and Materials Science of Soochow University have recently reported in Organic and Biomolecular Chemistry on an olefination process that involved the addition of a Grignard reagent onto a ketone.  The reaction forms an alkene in the presence of diethyl phosphite.

alkene

OBC paper

Posted in Cascade Reactions, Grignard, Methodology, Named Reactions | Leave a Comment »

 
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