Erick Carreira and co-workers have reported in ACIEE on their synthesis of this lipid that contains eleven chlorines.
Archive for the ‘Julia-Kocienski’ Category
Polychlorinated natural product
Posted by naturalproductman on July 12, 2011
Posted in Julia-Kocienski, Martin sulfurane, Methodology, Named Reactions, Named Reagents | Leave a Comment »
Towards Chlorahololide A
Posted by naturalproductman on February 3, 2010
Fa-Jun Nan and co-worker at the Chinese Academy of Sciences have recently published in Tetrahedron Letters on their progress towards chlorahololide A. An interesting structure in their route can be found in a Grignard addition of an bromo-magnesium bromo vinyl group that adds onto an aldehyde to ultimately form a bromo-butenolide.
Posted in Cascade Reactions, cross coupling, Heck, Julia-Kocienski, Methodology, Named Reactions, Palladium, Ring forming, Sesquiterpenes, Transition Metal | Leave a Comment »
Exiguolide Synthesis
Posted by naturalproductman on January 12, 2010
Exiguolide, a macrolide that specifically inhibits gamete fertilization of sea urchins but not the embryogenesis of the fertilized egg, was synthesized by Haruhiko Fuwa and co-workers at Tohoku University.
Posted in cross coupling, Julia-Kocienski, Macrocycles, Macrolides, Methodology, Polyenes, Suzuki-Miyaura, Transition Metal, Yamaguchi macrolactonization | Leave a Comment »
