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Archive for the ‘Michael’ Category

3 rings from 1

Posted by naturalproductman on October 3, 2012

Jiong Yang and co-workers from Texas A&M have reported in JOC on a transannular Michael reaction.

transannular Michael

JOC paper

Posted in Cascade Reactions, Methodology, Michael, Named Reactions, Ring forming, Transannular | Leave a Comment »

Substituted THPs from cascade

Posted by naturalproductman on February 23, 2012

Aurelio Csaky and co-workers from Universidad have reported in Organic Letters on an interesting way to form substituted tetrahydropyran rings.

THP

OL paper

Posted in Cascade Reactions, Methodology, Michael, Named Reactions | Leave a Comment »

Towards landomycinone

Posted by naturalproductman on January 25, 2012

Emmanuel Roulland and colleague at CNRS have reported in the European JOC on their progress towards landomycinone.

Michael

European JOC paper

Posted in Cascade Reactions, Methodology, Michael, Named Reactions, Polyketides | Leave a Comment »

Stenine synthesis

Posted by naturalproductman on December 19, 2011

Hongbin Zhang and co-workers at Yunnan University have reported in ACIEE on their synthesis of stenine.

stenine

ACIEE paper

Posted in Alkaloids, Cascade Reactions, Conjugate Additions, Methodology, Michael, Named Reactions | Leave a Comment »

Celastrol and sulfur adducts

Posted by naturalproductman on November 21, 2011

Richard Silverman and co-workers at Northwestern have reported in JACS on celastrol as a Michael acceptor.

HSP
JACS paper

Posted in Chemical Biology, Methodology, Michael, Named Reactions | Leave a Comment »

Transannular Michael

Posted by naturalproductman on November 21, 2011

Gerald Pattenden and colleague at the University of Nottingham have reported in Tetrahedron on the synthesis of ineleganolide via a Michael reaction.

synthesis
Tetrahedron paper

Posted in Cascade Reactions, Methodology, Michael, Named Reactions, Ring forming, Transannular | Leave a Comment »

Subincanadine C synthesis

Posted by naturalproductman on October 4, 2011

Hongbin Zhai and co-workers from Shanghai Institute of Organic Chemistry have reported in Organic Letters on the synthesis of subincanadine C.

alkaloid

OL paper

Posted in Alkaloids, Cascade Reactions, Conjugate Additions, Methodology, Michael, Named Reactions, Nickel, Transition Metal | Leave a Comment »

Organocatalytic oxy-Michael

Posted by naturalproductman on September 30, 2011

Seirjiro Matsubara and colleague at Kyoto University have reported in JACS on an organocatalytic oxy-Michael reaction.

intramolecular

JACS paper

Posted in Asymmetric, Conjugate Additions, Methodology, Michael, Named Reactions, Organocatalytic | Leave a Comment »

Aplyviolene synthesis

Posted by naturalproductman on September 26, 2011

Larry Overman and colleague have reported in JACS on a total synthesis of aplyviolene.  Surprisingly, the bromide in the alpha-bromo enone Michael acceptor substrate did not get displaced.

aplyviolene

JACS paper

Posted in Asymmetric, Cascade Reactions, Conjugate Additions, Diterpene, Methodology, Michael, Named Reactions, Total Synthesis | Leave a Comment »

Michael followed by Pictet-Spengler

Posted by naturalproductman on August 29, 2011

Xiaoyu Wu and co-workers at Shanghai University have reported in Chemistry a European Journal on a reaction that involves two named reaction using an indole tethered with a primary amine and an alkynoate as the subtrates.

Michael

Chemistry a European Journal paper

Posted in Cascade Reactions, Indoles, Indolizidines, Methodology, Michael, Named Reactions, Organocatalytic, Pictet-Spengler | Leave a Comment »

 
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