Imino-Nazarov reaction

Richard Hsung and co-workers published in Org Lett on an imino Nazarov reaction catalyzed by gold and silver.

OL paper

Cascade Nazarov

Carlos Saa and co-workers at Universidad de Santiago de Compostela in Spain have reported in ACIE on a cascade Nazarov reaction.

ACIE paper

Another Nazarov? Or not.

Zhang-Jie Shi and co-workers at Peking University have reported in Organic Letters on a palladium catalyzed cyclization process, which at first glance looked like it may be a Nazarov reaction but they proved that it probably is not a Nazarov reaction because of the observed kinetic isotope effect when they replaced the aryl hydrogens with deuteriums.

OL paper

Torqueselective Nazarov

Bernard Flynn and co-workers from Monash University in Australia have reported in Organic Letters on a Nazarov cyclization using a dienone precursor with an oxazolidinone precursor.  Tius has used a chiral auxilliary before either from some sugar or camphor source.

OL paper

Rocaglamide via Nazarov

Phil Magnus and co-workers have published in JACS on a Nazarov cyclization approach to access rocaglamide.

JACS paper

Roseophilin formal synthesis

Junbiao Chang and co-workers at Zhengzhou University have reported in JOC on a formal synthesis of roseophilin.

JOC paper

Asymmetric Nazarov

Magnus Rueping and co-worker from Aachen University have reported in Chemical Communications on an asymmetric Nazarov reaction that involves the addition of a bromine using N-triflylphosphoramide as the protonating source.  The substrate looks like the dienone that Dirk Trauner and co-worker used when he reported a scandium catalyzed Nazarov reaction excluding the bromination part.

Chem Comm paper

Nazarov cyclization via conjugate addition

Alison Frontier and co-workers at the University of Rochester have reported in JACS on a Nazarov cyclization

JACS paper

Synthesis of the nanolobatolide enantiomer

David Chen and co-workers at A*Star have reported in ACIEE on their synthesis of the enantiomer of nanolobatolide where the used a Nazarov reaction to access the five membered ring.

ACIEE paper

Indium catalyzed homo-Nazarov reaction

Stefan France and co-workers at Georgia Tech have reported in Organic Letters on a homo-Nazarov reaction catalyzed by indium (III) triflate.

 

OL paper