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Archive for the ‘Nozaki-Hiyama-Kishi’ Category

Abyssomicin synthesis

Posted by naturalproductman on April 23, 2012

Radomir Saicic and colleague at the University of Belgrade in Serbia have reported in ACIE on the synthesis of atrop-abyssomicin.

abyssomycin

ACIE paper

Posted in Asymmetric, Cascade Reactions, Chromium, Methodology, Named Reactions, Nickel, Nozaki-Hiyama-Kishi, Total Synthesis, Transition Metal | Leave a Comment »

NHK coupling asymmetrically

Posted by naturalproductman on March 29, 2012

The Nozaki-Hiyama-Kishi coupling couples an a R-halide group with an aldehyde.  Kishi and co-workers have reported on a catalytic, asymmetric version in JACS recently.
NHK

JACS paper

Posted in Asymmetric, Chromium, cross coupling, Methodology, Named Reactions, Nickel, Nozaki-Hiyama-Kishi, Transition Metal | Leave a Comment »

NHK Reaction

Posted by naturalproductman on March 22, 2010

Thomas Horstmann and co-workers from Eisai have recently reported in Tetrahedron on an alternative to make Baylis-Hillman adducts using the Nozaki-Hiyama-Kishi coupling protocol.  The starting material is of course the usual aldehyde from the NHK reaction but also an alpha-bromo-enone.

baylis hillman

TL paper

Posted in Asymmetric, Chromium, Methodology, Nickel, Nozaki-Hiyama-Kishi, Transition Metal | Leave a Comment »

 
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