Abyssomicin synthesis

Radomir Saicic and colleague at the University of Belgrade in Serbia have reported in ACIE on the synthesis of atrop-abyssomicin.

ACIE paper

NHK coupling asymmetrically

The Nozaki-Hiyama-Kishi coupling couples an a R-halide group with an aldehyde.  Kishi and co-workers have reported on a catalytic, asymmetric version in JACS recently.

JACS paper

NHK Reaction

Thomas Horstmann and co-workers from Eisai have recently reported in Tetrahedron on an alternative to make Baylis-Hillman adducts using the Nozaki-Hiyama-Kishi coupling protocol.  The starting material is of course the usual aldehyde from the NHK reaction but also an alpha-bromo-enone.

TL paper