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Archive for the ‘oxy-Cope rearrangement’ Category

Ireland Claisen/Cope rearrangement

Posted by naturalproductman on June 30, 2014

James Leighton and co-workers reported in JACS on a mechanistic study of a tandem Ireland Claisen/Cope rearrangement reaction to form some polycyclic rings.

oxy Cope

JACS paper

Posted in Cascade Reactions, Claisen rearrangement, Cope rearrangement, Mechanistic, Methodology, Named Reactions, oxy-Cope rearrangement | Leave a Comment »

Vittatalactone Synthesis

Posted by naturalproductman on January 31, 2011

Christoph Schneider and co-workers at Universitat Leipzig have published in Chem Comm on their total synthesis of vittatalactone, which involves an oxy-Cope rearrangement to place the carbons in the correct position with unsaturation followed by an asymmetric reduction to yield the methyls in the correct stereochemical arrangement.

vittatalactone

 

Chem Comm paper

Posted in Cascade Reactions, Cope rearrangement, Iridium, Methodology, Named Reactions, oxy-Cope rearrangement, Pericyclic reactions, Sigmatropic Rearrangements, Transition Metal | Leave a Comment »

1,2-Addition/Oxy-Cope

Posted by naturalproductman on August 27, 2010

Jeremy Wulff and co-workers at the University of Victoria have published in Organic Letters on a tandem 1,2-addition/oxy-Cope reaction to access a bicyclic sulfone.

bicyclic sulfone

OL paper

Posted in Cascade Reactions, Methodology, Named Reactions, oxy-Cope rearrangement, Pericyclic reactions, Ring forming, Sigmatropic Rearrangements | Leave a Comment »

 
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