Merrilactone synthesis

Hongbin Zhai and co-workers at the Chinese Academy of Sciences have published in ACIE on the synthesis of merrilactone where they used a Pauson-Khand reaction as one of the key steps.

ACIE paper

Pauson-Khand without CO gas

Tsumoru Morimoto and co-workers at NAIST (Nara Institute of Science and Technology) have reported on a rhodium catalyzed Pauson-Khand type reaction using glyceraldehyde as the CO source.

Synlett paper

Penostatin B synthesis

Kozo Shishido and co-workers at the University of Tokushima have reported in Organic Letters on the synthesis of penostatin B relying on a relay ring closing metathesis.

OL paper

Scalable syntheses of axinellamines

Phil Baran and co-workers have reported in JACS on their scalable synthesis of axinellamines.

JACS paper

Huperzine Q synthesis

Hiromitsu Takayama and co-workers at Chiba University have reported in ACIEE on their synthesis of huperzine Q featuring a Pauson-Khand reaction to introduce the cyclopentenone.

ACIEE paper

Meloscine Synthesis

Chisato Mukai and colleagues have reported in Organic Letters on their synthesis of meloscine via a Pauson-Khand reaction.

 

OL paper

Rhodium Catalyzed Hydroformylation

I’m reminded of the Pauson-Khand reaction from this Organic Letters publication by Bernhard Breit and co-workers from FRIAS on this rhodium catalyzed hydroformylation reaction of an alkene.

OL paper

Rhodium Catalyzed Cycloaddition

Young Keun Chung and co-workers at Seoul National University have published in ACIEE on a Pauson Khand reaction using an alcohol as the CO source and rhodium as the metal.

ACIEE paper

Total Syntheses of a Few Alkaloids

Chisato Mukai and co-workers from Kanazawa University have recently reported in JOC on the total syntheses of fawcettimine and lycoposperramine-B from a common tricyclic lactone intermediate.  The common precursor was synthesized from a Pauson-Khand reaction of an enyne starting material.

JOC paper

Access to Indenones using Palladium

Jin-Heng Li and co-workers from Hunan National University have recently published in JOC on a three component cyclization process that combines carbon monoxide, allylic carbonate and a benzyne to form a new ring to access indenone ring systems. They have combined the Tsuji-Trost, Pauson-Khand-like and benzyne chemistry to do some beautiful chemistry here.

JOC paper