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Archive for the ‘Pictet-Spengler’ Category

Michael followed by Pictet-Spengler

Posted by naturalproductman on August 29, 2011

Xiaoyu Wu and co-workers at Shanghai University have reported in Chemistry a European Journal on a reaction that involves two named reaction using an indole tethered with a primary amine and an alkynoate as the subtrates.

Michael

Chemistry a European Journal paper

Posted in Cascade Reactions, Indoles, Indolizidines, Methodology, Michael, Named Reactions, Organocatalytic, Pictet-Spengler | Leave a Comment »

Arizonin C1 synthesis

Posted by naturalproductman on July 3, 2011

Reinhard Bruckner and co-workers at Universitat Freiburg have reported in the European JOC on their synthesis of arizonin C1.

arizonin C1

European JOC paper

Posted in Cascade Reactions, Dotz benzannulation, Knoevenagel condensation, Methodology, Named Reactions, Pictet-Spengler, Total Synthesis, Transition Metal | Leave a Comment »

Tadalafil Analogs

Posted by naturalproductman on May 5, 2011

Benoit Deprez and co-workers at Universite Lille Nord de France have reported in the Journal of Medicinal Chemistry on the synthesis and activity relationships of tadalafil.

tadalafil

JMC paper

Posted in Named Reactions, Pictet-Spengler, SAR studies | Leave a Comment »

Alstoscholarine Syntheses

Posted by naturalproductman on April 3, 2011

Jieping Zhu and co-workers at CNRS have reported in ACIEE on a synthesis of alstoscholarine – what a scholarly piece of work.

alstoscholarine

ACIEE paper

Posted in Alkaloids, C2-Symmetric, Cascade Reactions, Methodology, Named Reactions, Pictet-Spengler, Takeda olefination | Leave a Comment »

Phalarine Synthesis

Posted by naturalproductman on May 28, 2010

Samuel Danishefsky and co-workers have published in JACS on the total synthesis of phalarine from an amino acid.

phalarine

JACS paper

Posted in Alkaloids, Cascade Reactions, Methodology, Named Reactions, Pictet-Spengler, retro-Mannich | Leave a Comment »

Michael Addition followed by Pictet-Spengler

Posted by naturalproductman on April 6, 2010

Gang Zhao and co-workers from the Shanghai Institute of Organic Chemistry have recently published in Chemical Communications on a one pot three component coupling process that involves a Michael addition followed by a Pictet Spengler reaction.

mcc

Chemical Communications paper

Posted in Asymmetric, Cascade Reactions, Methodology, Michael, Multi-Component Coupling, Named Reactions, Pictet-Spengler | Leave a Comment »

Tangutorine Synthesis

Posted by naturalproductman on February 8, 2010

Here’s a nice alkaloid total synthesis by Yasumasa Hamada and co-workers at Chiba University.
tangutorine

OL paper

Posted in Cascade Reactions, Methodology, Named Reactions, Palladium, Pictet-Spengler, Ring forming, Transition Metal | Leave a Comment »

 
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