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Archive for the ‘Reformatsky’ Category

Ophiobolin synthesis

Posted by naturalproductman on September 15, 2011

Masahisa Nakada and co-workers have reported in ACIEE on a synthesis of ophiobolin where the seven membered ring was accessed via a ring closing metathesis.

ophiobolin

ACIEE paper

Posted in Cancer, Cascade Reactions, melanoma, Metathesis, Methodology, Named Reactions, Reformatsky, Ring forming, Ruthenium, Sesquiterpenoids, Seven-Membered Rings, Transition Metal | Leave a Comment »

Reformatsky-Claisen Cascade

Posted by naturalproductman on November 19, 2010

Jeffrey Johnson and co-workers at UNC have published in JACS on a Refoormatzky-Claisen condensation cascade reaction where the second enolate generated opens a beta-lactone.

beta lactone

 

JACS paper

Posted in Cascade Reactions, Claisen condensation, Methodology, Multi-Component Coupling, Named Reactions, Reformatsky, Ring Opening, Transition Metal, Zinc | Leave a Comment »

 
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