Shi epoxidation approach for glabrescol

Jin Qu and co-workers from Nankai University have reported in Organic Letters on a synthesis of a polytetrahydrofuranyl compound using Shi epoxidation of a polyolefin intermediate.

OL paper

Omaezakianol Synthesis

Poly-tetrahydrofuranyl compounds usually have some interesting biological activity.  Zhaoming Xiong and co-workers at Boehringer Ingelheim in Connecticut have recently published in Organic Letters on the synthesis of omaezakianol by epoxidizing a polyolefin using Shi’s catalyst followed by an acid catalyzed polyepoxide opening cascade reaction.

OL paper