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Archive for the ‘Staudinger’ Category

Clavolonine Synthesis

Posted by naturalproductman on March 11, 2011

Hiromichi Fujioka and co-workers from Osaka University have published in Organic Letters on a total synthesis of clavolonine where they made use of a Staudinger reaction to form one of the piperidines.

clavolonine

OL paper

Posted in Alkaloids, Aza-Wittig, Methodology, Named Reactions, Staudinger | Leave a Comment »

Indolo[1,2-c]quinazoline Synthesis via Multi-Component Coupling Strategy

Posted by naturalproductman on January 12, 2011

Ming-Wu Ding and co-workers from the Central China Normal University have published in Organic and Biomolecular Chemistry on a multi-component coupling approach followed by a Staudinger/Aza-Wittig reaction.

MCC

 

OBC paper

Posted in Aza-Wittig, Cascade Reactions, Methodology, Multi-Component Coupling, Named Reactions, Staudinger, Ugi | Leave a Comment »

Ugi then Staudinger-Aza-Wittig

Posted by naturalproductman on July 27, 2010

Tomas Torroba and co-workers from the Universidad de Burgos have published on an Ugi reaction followed by a Staudinger-Aza-Wittig cyclization.  The key was that the carboxylic acid partner in the Ugi reaction was tethered by an azide group.

cascade

Tetrahedron paper

Posted in Aza-Wittig, Cascade Reactions, Methodology, Named Reactions, Staudinger, Ugi | Leave a Comment »

Circumdatin H Synthesis

Posted by naturalproductman on January 9, 2010

Subhas Bose and co-worker at the Indian Institute of Chemical Technology have recently published in Chemical Communications on the synthesis of circumdatin H, an NADH oxidase inhibitor.  The key reaction was an Eguchi-aza-Wittig reaction to form the carbon nitrogen double bond.

circumdatin H
Synthesis paper

Posted in Alkaloids, Eguchi aza-Wittig, Methodology, Ring forming, Staudinger | Leave a Comment »

 
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