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Archive for the ‘Ugi’ Category

Titanium mediated Ugi reaction

Posted by naturalproductman on September 7, 2012

Marco Ciufolini and co-workers have reported in Organic Letters on an Ugi reaction.

Ugi

OL paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling, Named Reactions, Titanium, Transition Metal, Ugi | Leave a Comment »

Interrupted Ugi reaction

Posted by naturalproductman on July 16, 2012

Erik Sorensen and co-workers have reported in Chemical Science on their synthesis of 11-methoxy mitragynine.

Ugi

Chemical Science paper

Posted in Alkaloids, Cascade Reactions, Methodology, Named Reactions, Ugi | Leave a Comment »

Tubulysin mimic

Posted by naturalproductman on April 30, 2011

Ludger Wessjohan and co-workers have reported in JACS on bioactive tubulysin analogs.  One of them had an IC50 value of 0.14 nM against HT-29 cells.

tubulysin

JACS paper

Posted in Methodology, Named Reactions, Peptides, Ugi, Unnatural Products | Leave a Comment »

Indolo[1,2-c]quinazoline Synthesis via Multi-Component Coupling Strategy

Posted by naturalproductman on January 12, 2011

Ming-Wu Ding and co-workers from the Central China Normal University have published in Organic and Biomolecular Chemistry on a multi-component coupling approach followed by a Staudinger/Aza-Wittig reaction.

MCC

 

OBC paper

Posted in Aza-Wittig, Cascade Reactions, Methodology, Multi-Component Coupling, Named Reactions, Staudinger, Ugi | Leave a Comment »

Towards Massadine

Posted by naturalproductman on December 8, 2010

Erick Carreira and co-workers at ETH have published in Organic Letters on their progress towards massadine where an Ugi transformation was used to access the quaternary stereocenter.

Ugi
OL paper

Posted in Alkaloids, Cascade Reactions, Methodology, Multi-Component Coupling, Named Reactions, Ugi | Leave a Comment »

Azido-Ugi Five Component Reaction

Posted by naturalproductman on August 11, 2010

Leonid Voskressensky and co-workers from the Russian People’s Friendship University have published in Organic Letters on a multicomponent coupling reaction between an isocyanide methyl ester, ammonium chloride, sodium azide and a ketone to form benzodiazapine structures.

multicomponent

OL paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling, Named Reactions, Ring forming, Ugi | Leave a Comment »

Ugi then Staudinger-Aza-Wittig

Posted by naturalproductman on July 27, 2010

Tomas Torroba and co-workers from the Universidad de Burgos have published on an Ugi reaction followed by a Staudinger-Aza-Wittig cyclization.  The key was that the carboxylic acid partner in the Ugi reaction was tethered by an azide group.

cascade

Tetrahedron paper

Posted in Aza-Wittig, Cascade Reactions, Methodology, Named Reactions, Staudinger, Ugi | Leave a Comment »

Desymmetrization then Ugi

Posted by naturalproductman on June 25, 2010

Romano Orru and co-workers at Vrije Universiteit Amsterdam have published in ACIEE on a diastereoselective Ugi reaction after an enzyme catalyzed desymmetrization of a meso compound using monoamine oxidase N (MAO-N).

Ugi

ACIEE paper

Posted in Cascade Reactions, Enzymatic, Methodology, Multi-Component Coupling, Named Reactions, Ugi | Leave a Comment »

Ugi-Approach for 4,4-Disubstituted Piperidines

Posted by naturalproductman on April 29, 2010

Guillaume Laconde and co-workers at INSERM have recently reported in Tetrahedron Letters on an Ugi reaction to synthesize 4-aminopiperidine-4-carboxylic acids.

ugi

Tetraheron Letters paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling, Named Reactions, Ugi | Leave a Comment »

Substituted morpholine-carboxamides

Posted by naturalproductman on March 22, 2010

Xiaochuan Chen and co-workers at Sichuan University have recently reported on an Ugi reaction that gave rise to substituted morpholine-carboxamides.

ugi

Synlett paper

Posted in Cascade Reactions, Diastereoselective, Methodology, Multi-Component Coupling, Named Reactions, Ugi | Leave a Comment »

 
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