Tormesol via Wittig

Dongjoo Lee and co-workers at Dankook University have reported in Tetrahedron on the synthesis of tormesol.  The seven membered ring was acquired from a Horner-Wadsworth-Emmons reaction.

Tetrahedron paper

Asymmetric Wittig reaction

Luca Bernardi and co-workers have reported in Synlett on an asymmetric Wittig reaction.

Synlett paper

Vigulariol and sclerophytin A syntheses

Michael Crimmins and co-workers at UNC have reported in Organic Letters on the syntheses of two similar looking natural products, vigulariol and sclerophytin A.

OL paper

Olefination with an alkyne

Kurt Gothelf and co-workers from Aarhus University have reported in Organic Letters on a beta-olefination process involving an alkynoate and an aldehyde in the presence of 1,3,5-triaza-7-phospha-adamantane (PTA).

OL paper

Chivosazole Synthesis

Markus Kalesse and co-workers at Leibniz Universitat Hannover in Germany have published in JACS on the total synthesis of Chivosazole.

JACS paper

Aza-Wittig and Aza-retro-Claisen

Robert Boeckman and co-workers at the University of Rochester have recently published in Organic Letters on an aza-Wittig/aza-retro-Claisen reaction to yield heterocyclic nitrogen containing compounds.

OL paper

Tandem Oxidation-Wittig

Richard Taylor and co-workers at the University of York have recently published in Synlett on a tandem approach to synthesize dibromo-beta-substituted enone from an alpha hydroxy ketone.   Hydrazine was condensed with the carbonyl and a Suzuki-Miyaura cross coupling followed to form a pyrazole ring.

Synlett paper