The Jacobsen and Hoye groups have recently independently published on the synthesis of peloruside. Jacobsen et al took advantage of his enantioselective epoxide opening reaction while Hoye’s group used a relay ring closing metathesis to form the pyran moiety found in peloruside.
Exiguolide, a macrolide that specifically inhibits gamete fertilization of sea urchins but not the embryogenesis of the fertilized egg, was synthesized by Haruhiko Fuwa and co-workers at Tohoku University.