Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for the ‘Yamaguchi macrolactonization’ Category

Callipeltoside synthesis

Posted by naturalproductman on August 23, 2012

Steven Ley and co-workers have reported in ACIE on the synthesis of callipeltoside.

macrolide

ACIE paper

Posted in Macrolides, Methodology, Named Reactions, Yamaguchi macrolactonization | Leave a Comment »

Amphidinolide F synthesis

Posted by naturalproductman on July 5, 2012

Rich Carter and colleague have reported in ACIE on the synthesis of amphidinolide F.

amphidinolide F

ACIE paper

Posted in Cascade Reactions, Methodology, Named Reactions, Silver, Transition Metal, Vedejs olefination, Yamaguchi macrolactonization | Leave a Comment »

Syntheses of Peloruside

Posted by naturalproductman on July 20, 2010

The Jacobsen and Hoye groups have recently independently published on the synthesis of peloruside.  Jacobsen et al took advantage of his enantioselective epoxide opening reaction while Hoye’s group used a relay ring closing metathesis to form the pyran moiety found in peloruside.

epoxide

Hoye
ACIEE paper 1

ACIEE paper 2

Posted in Metathesis, Methodology, Named Reactions, Polyketides, Total Synthesis, Yamaguchi macrolactonization | Leave a Comment »

Exiguolide Synthesis

Posted by naturalproductman on January 12, 2010

Exiguolide, a macrolide that specifically inhibits gamete fertilization of sea urchins but not the embryogenesis of the fertilized egg, was synthesized by Haruhiko Fuwa and co-workers at Tohoku University.

exiguolide

OL paper

Posted in cross coupling, Julia-Kocienski, Macrocycles, Macrolides, Methodology, Polyenes, Suzuki-Miyaura, Transition Metal, Yamaguchi macrolactonization | Leave a Comment »

 
Follow

Get every new post delivered to your Inbox.

Join 69 other followers