Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for the ‘Yamamoto rearrangement’ Category

Synthesis of Cymbodiacetal

Posted by naturalproductman on November 19, 2010

Christopher Hayes and co-workers from the University of Nottingham have published in JOC on the total synthesis of cymbodiacetal – a symmetrical molecule.  One of the key steps was the opening of a methylepoxide via Yamamoto rearrangement and a dimerization using a hetero-Diels-Alder transformation.

cymbodiacetal

 

JOC paper

Posted in Cascade Reactions, Cycloaddition, Diels-Alder, Methodology, Named Reactions, Pericyclic reactions, Total Synthesis, Yamamoto rearrangement | Leave a Comment »

 
Follow

Get every new post delivered to your Inbox.

Join 77 other followers